protein

Recombinant Human Mitogen-Activated Protein Kinase 3, Active

MBS142758

0.01 mg

840 USD

Recombinant Protein

Recombinant Human Mitogen-Activated Protein Kinase 3, Active

Mitogen-Activated Protein Kinase 3

MAPK3 Human, Active; Mitogen-Activated Protein Kinase 3 Human Recombinant, Active; Mitogen-activated protein kinase 3; EC 2.7.11.24; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAPK 1; p44-ERK1; ERT2; p44-MAPK; Microtubule-associated protein 2 kinase; ERK1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; MGC20180; MAPK3 Active

mitogen-activated protein kinase 3 isoform 2; Mitogen-activated protein kinase 3; mitogen-activated protein kinase 3; MAP kinase isoform p44; MAPK 1; extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; insulin-stimulated MAP2 kinase; microtubule-associated protein 2 kinase; mitogen-activated protein kinase 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1

MAPK3

MAPK3; MAPK3; ERK1; ERT2; ERK-1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; ERK1; PRKM3; MAP kinase 3; MAPK 3; ERK-1; p44-MAPK

MK03_HUMAN

E Coli

357

Greater than 95% as determined by SDS-PAGE.

ERK1/MAPK3 is supplied as 0.15mg/ml containing 50mM Tris-HCl, 150mM NaCl, 1mM DTT, 50% glycerol, pH 8.5. Sterile Filtered clear solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.Avoid multiple freeze-thaw cycles.

Unit Defenition: No protease activity detectable, specific activity > 15.000 U*/mg (*1 U = 1 pmol/min transferred to myelin basic protein at 30 degree C).

PROTEIN KINASES; Enzymes; Mitogen-Activated Protein Kinase

Description: ERK1/MAPK3 Recombinant is a highly active form produced by phosphorylation of the purified ERK1/MAPK3 in vitro with MEK1 is a non-glycosylated polypeptide having a molecular mass of 43.6 kDa. ERK1/MAPK3 is purified by proprietary chromatographic techniques. Introduction: Extracellular signal-regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinaseintracellular signalingmolecules which are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virusinfection, ligands for heterotrimeric G protein-coupled receptors, transforming agents, and carcinogens, activate the ERK pathway.The term, "extracellular signal-regulated kinases", is sometimes used as a synonym for mitogen-activated protein kinase(MAPK), but has more recently been adopted for a specific subset of the mammalianMAPK family. In the MAPK/ERK pathway, Rasactivates c-Raf, followed by MEKand then MAPK1/2 (below). Ras is typically activated by growth hormones through receptor tyrosine kinasesand GRB2/SOS, but may also receive other signals. ERKs are known to activate many transcription factors and some downstream protein kinases. Disruption of the ERK pathway is common in cancers, especially Ras, c-Raf and receptors such as HER2.Mitogen-activated protein kinase 3 (MAPK3) is also known as "extracellular signal-regulated kinase 1" (ERK1). Transgenic gene knockoutmice lacking MAPK3 are viable and it is thought that MAPK1 can fulfill most MAPK3 functions in most cells. The main exception is in T cells. Mice lacking MAPK3 have reduced T cell development past the CD4+CD8+ stage.

91718897

NP_001035145.1

NM_001040056.2

P27361

40,088 Da

AGE/RAGE Pathway 698754!!ALK1 Signaling Events Pathway 137968!!ARMS-mediated Activation Pathway 106466!!ATF-2 Transcription Factor Network Pathway 138006!!Activated TLR4 Signalling Pathway 106400!!Activation Of The AP-1 Family Of Transcription Factors Pathway 160139!!Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Adherens Junction Pathway 83070!!Adherens Junction Pathway 481

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]

0.01 mg

840 USD