Recombinant Human Casein Kinase 2 beta Active | MyBioSource MBS142755 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Casein Kinase 2 beta Active

catalog :

MBS142755

quantity :

0.003 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142755

products type :

Recombinant Protein

products full name :

Recombinant Human Casein Kinase 2 beta Active

products short name :

Casein Kinase 2 beta Active

products name syn :

CSNK2B Human, Active; Casein Kinase 2 beta Human Recombinant, Active; Casein kinase II subunit beta; CK II beta; Phosvitin; G5a; CK2B; CK2N; CSK2B; MGC138222; MGC138224; CK2b Active

other names :

casein kinase II subunit beta isoform 2; Casein kinase II subunit beta; casein kinase II subunit beta; CK II beta; CSNK2B-LY6G5B-532; CSNK2B-LY6G5B-560; Casein kinase II beta subunit; alternative name: G5a, phosvitin; casein kinase II b subunit splicing isoform 318; casein kinase II b subunit splicing isoform 660; casein kinase II b subunit splicing isoform 806; chimera CSNK2B-LY6G5B splicing isoform 532; chimera CSNK2B-LY6G5B splicing isoform 560; protein G5a; casein kinase 2, beta polypeptide; Phosvitin; Protein G5a

products gene name :

CK2b

other gene names :

CSNK2B; CSNK2B; G5A; CK2B; CK2N; CSK2B; CK2N; G5A; CK II beta

uniprot entry name :

CSK2B_HUMAN

host :

E Coli

sequence length :

212

purity :

Greater than 95% as determined by SDS-PAGE.

form :

CSNK2B lyophilized from 25mM Tris-HCl, 500mM NaCl, 1mM DTT, 1mM EDTA, protease inhibitor cocktail, pH 8.5. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized CSNK2B although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CSNK2B should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

other info1 :

Unit Defenition: 1U = 1 umol/min at 37 degree C) using the synthetic peptide RRRDDDSDDD.

other info2 :

Solubility: Solubilize in distilled H2O or 50% glycerol. Biological Activity: Specific activity > 1U/mg.

products categories :

PROTEIN KINASES; Enzymes; Casein Kinase

products description :

Description: Casein Kinase 2 beta Human Recombinant is a non-glycosylated polypeptide having a molecular mass of 24.9 kDa. Casein Kinase 2 is purified by proprietary chromatographic techniques. Introduction: The Casein kinase 2 (EC2.7.11.1) is a serine/threonine-selective protein kinasethat is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cyclecontrol, DNA repair, regulation of the circadian rhythmand other cellular processes.Casein kinase 2 activity has been reported to be activated following Wnt signaling pathwayactivation. A Pertussis toxin-sensitive G proteinand Disheveled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2.Mice that lack casein kinase 2 alpha prime have a defect in the morphology of developing sperm.

ncbi gi num :

538260597

ncbi acc num :

NP_001269314.1

ncbi gb acc num :

NM_001282385.1

uniprot acc num :

P67870

ncbi mol weight :

24,942 Da

ncbi pathways :

ALK1 Signaling Events Pathway (137968); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Axon Guidance Pathway (105688); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Condensation Of Prometaphase Chromosomes Pathway (730316); Developmental Biology Pathway (477129); Disease Pathway (530764); Epstein-Barr Virus Infection Pathway (585562)

ncbi summary :

This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

uniprot summary :

CK2B: a regulatory subunit of the casein kinase 2 holoenzyme. Exists as a tetramer composed of two catalytic subunits, alpha and alpha-prime, and two regulatory beta subunits. The beta subunits undergo autophosphorylation. Plays a complex role in regulating the basal catalytic activity of the alpha subunit. Participates in Wnt signaling. Protein type: Protein kinase, regulatory subunit. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: cytoplasm; plasma membrane; protein kinase CK2 complex; PcG protein complex; cytosol; nucleus. Molecular Function: protein domain specific binding; protein serine/threonine kinase activity; identical protein binding; protein binding; metal ion binding; protein kinase regulator activity; transcription factor binding; receptor binding. Biological Process: negative regulation of cell proliferation; axon guidance; positive regulation of activin receptor signaling pathway; Wnt receptor signaling pathway; cellular protein complex assembly; regulation of DNA binding; adiponectin-mediated signaling pathway; mitotic cell cycle; negative regulation of blood vessel endothelial cell migration; regulation of protein kinase activity; signal transduction; protein amino acid phosphorylation

size1 :

0.003 mg

price1 :

220 USD

more info or order :

MyBioSource product webpage