Recombinant Human Heat Shock Protein 27 | MyBioSource MBS142706 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Heat Shock Protein 27

catalog :

MBS142706

quantity :

0.01 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142706

products type :

Recombinant Protein

products full name :

Recombinant Human Heat Shock Protein 27

products short name :

Heat Shock Protein 27

products name syn :

HSP27 Human; Heat Shock Protein 27 Human Recombinant; HSPB1; CMT2F; HMN2B; HSP27; HSP28; HSP25; Heat shock protein beta-1; Heat shock 27 kDa protein; Stress-responsive protein 27; SRP27; HS.76067; DKFZp586P1322

other names :

heat shock protein beta-1; Heat shock protein beta-1; heat shock protein beta-1; 28 kDa heat shock protein; HSP 27; epididymis secretory protein Li 102; estrogen-regulated 24 kDa protein; heat shock 27 kDa protein; heat shock 27kD protein 1; stress-responsive protein 27; heat shock 27kDa protein 1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27

products gene name :

HSP27

other gene names :

HSPB1; HSPB1; CMT2F; HMN2B; HSP27; HSP28; Hsp25; SRP27; HS.76067; HEL-S-102; HSP27; HSP28; HspB1; HSP 27; SRP27

uniprot entry name :

HSPB1_HUMAN

host :

E Coli

sequence length :

205

sequence :

MTERRVPFSL LRGPSWDPFR DWYPHSRLFD QAFGLPRLPE EWSQWLGGSS WPGYVRPLPP AAIESPAVAA PAYSRALSRQ LSSGVSEIRH TADRWRVSLD VNHFAPDELT VKTKDGVVEI TGKHEERQDE HGYISRCFTR KYTLPPGVDP TQVSSSLSPE GTLTVEAPMP KLATQSNEIT IPVTFESRAQ LGGPEAAKSD ETAAK.

purity :

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The HSP27 protein solution contains 20mM Hepes pH-7.5, 1mM DTT and 100mM KCl. Sterile Filtered colorless solution.

storage stability :

HSP-27 although stable at 4 degree C for 1 week, should be stored below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

products categories :

HEAT SHOCK PROTEINS; Recombinant Proteins; Heat Shock Protein

products description :

Description: Recombinant Human HSP-27 produced in E Coli is a single, non-glycosylated polypeptide chain containing 205 amino acids and having a molecular mass of 22.7 kDa. Hsp27 was over-expressed in E Coli and purified by conventional chromatography. Introduction: HSP27 (also known as the Estrogen-Regulated 24K protein, and hsp 28) is a member of the mammalian small heat shock protein family. Hsp27 is expressed constitutively in many tissues and its expression is increased to high levels after various types of stress including elevated temperatures, toxic metals, drugs and oxidants. Also, Hsp27 is phosphorylated in vivo on three phosphorylation sites (Ser15, Ser78 and Ser82) by protein kinases including MAPKAP kinase 2 and the stress-activated protein kinase SAPK2 (p38).

ncbi gi num :

4504517

ncbi acc num :

NP_001531.1

ncbi gb acc num :

NM_001540.3

uniprot acc num :

P04792

ncbi mol weight :

22,783 Da

ncbi pathways :

AUF1 (hnRNP D0) Destabilizes MRNA Pathway (187212); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); FAS Pathway And Stress Induction Of HSP Regulation (198894); Gene Expression Pathway (105937); IL-3 Signaling Pathway (198881); IL-6 Signaling Pathway (198864); MAPK Signaling Pathway (198779)

ncbi summary :

The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008]

uniprot summary :

HSP27: a small heat shock protein that is regulated both transcriptionally and posttranslationally. Modulates actin polymerization and reorganization. Its expression level increases several-fold in response to stress and is phosphorylated by MAPKAP kinase 2. Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock. Protein type: Heat shock protein; Motility/polarity/chemotaxis; Chaperone. Chromosomal Location of Human Ortholog: 7q11.23. Cellular Component: proteasome complex; extracellular space; cytoskeleton; focal adhesion; cytoplasm; plasma membrane; spindle; nucleus; Z disc; cytosol. Molecular Function: identical protein binding; protein kinase C inhibitor activity; ubiquitin binding; protein binding; protein kinase C binding; protein kinase binding. Biological Process: positive regulation of tumor necrosis factor biosynthetic process; response to virus; positive regulation of blood vessel endothelial cell migration; response to unfolded protein; positive regulation of interleukin-1 beta production; retinal homeostasis; positive regulation of angiogenesis; negative regulation of protein kinase activity; gene expression; regulation of I-kappaB kinase/NF-kappaB cascade; vascular endothelial growth factor receptor signaling pathway; cell motility; regulation of translational initiation; negative regulation of apoptosis. Disease: Neuronopathy, Distal Hereditary Motor, Type Iib; Charcot-marie-tooth Disease, Axonal, Type 2f

size1 :

0.01 mg

price1 :

140 USD

size2 :

0.05 mg

price2 :

205

size3 :

1 mg

price3 :

1885

more info or order :

MyBioSource product webpage