Recombinant Human Heat Shock 22 kDa Protein-8 | MyBioSource MBS142705 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Heat Shock 22 kDa Protein-8

catalog :

MBS142705

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142705

products type :

Recombinant Protein

products full name :

Recombinant Human Heat Shock 22 kDa Protein-8

products short name :

Heat Shock 22 kDa Protein-8

products name syn :

HSPB8 Human; Heat Shock Protein 22 kDa Protein-8 Human Recombinant; HSPB8; H11; HMN2; CMT2L; DHMN2; E2IG1; HMN2A; HSP22; Heat shock protein beta-8; Alpha-crystallin C chain; Small stress protein-like protein HSP22; E2-induced gene 1 protein; Protein kinase H11; CRYAC

other names :

heat shock protein beta-8; Heat shock protein beta-8; heat shock protein beta-8; E2-induced gene 1 protein; alpha-crystallin C chain; heat shock 27kDa protein 8; protein kinase H11; small stress protein-like protein HSP22; heat shock 22kDa protein 8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22

products gene name :

HSPB8

other gene names :

HSPB8; HSPB8; H11; HMN2; CMT2L; DHMN2; E2IG1; HMN2A; HSP22; CRYAC; E2IG1; HSP22; HspB8

uniprot entry name :

HSPB8_HUMAN

host :

E Coli

sequence length :

196

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The HSPB8 protein was lyophilized from a concentrated (1mg/ml) solution containing 20mM Tris-acetate, pH-7.6, 10mM NaCl, 0.1mM EDTA, 0.1mM PMSF, 15mM ?-ME. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized HSPB8 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution HSPB8 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

app notes :

Immunological Activity: Immunoreactivity is confirmed by reaction with monoclonal mouse antibodies against HSPB8.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized HSPB8 in sterile 18M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

products categories :

HEAT SHOCK PROTEINS; Recombinant Proteins; Heat Shock Protein

products description :

Description: Recombinant Human Heat Shock Protein 22 kDa Protein-8 is a full-length human HSP22 with an MW of 21604 Dalton produced in E Coli. Introduction: HSPB8 displays temperature-dependent chaperone activity. HSPB8 acts as a mn(2+)-dependent serine-threonine- specific protein kinase. we are not convinced that this is its true role. Defects in HSPB8 are a cause of distal hereditary motor neuropathy type ii (DHMN2) also known as distal spinal muscular atrophy (DSMA) and spinal muscular atrophy of the charcot-marie-tooth type. it is an autosomal dominant disorder of lower motor neurons characterized by distal muscle weakness.

ncbi gi num :

7657146

ncbi acc num :

NP_055180.1

ncbi gb acc num :

NM_014365.2

uniprot acc num :

Q9UJY1

ncbi mol weight :

21,604 Da

ncbi summary :

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

uniprot summary :

HSPB8: Displays temperature-dependent chaperone activity. Monomer. Interacts with HSPB1. Interacts with DNAJB6. By 17-beta-estradiol. Predominantly expressed in skeletal muscle and heart. Belongs to the small heat shock protein (HSP20) family. Protein type: Heat shock protein. Chromosomal Location of Human Ortholog: 12q24.23. Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; intracellular; nucleus. Molecular Function: identical protein binding; protein binding; protein kinase activity. Disease: Charcot-marie-tooth Disease, Axonal, Type 2l; Neuronopathy, Distal Hereditary Motor, Type Iia

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

0.1 mg

price3 :

1305

more info or order :

MyBioSource product webpage