protein

Recombinant Human Heat Shock Factor Binding Protein- 1

MBS142691

0.01 mg

140 USD

Recombinant Protein

Recombinant Human Heat Shock Factor Binding Protein- 1

Heat Shock Factor Binding Protein- 1

HSBP 1 Human; Heat Shock Factor Binding Protein - 1 Human Recombinant; NPC-A-13; HSBP1; Heat shock factor-binding protein 1; Nasopharyngeal carcinoma-associated antigen 13; HSF1BP; DKFZp686D1664; DKFZp686O24200

heat shock factor-binding protein 1; Heat shock factor-binding protein 1; heat shock factor-binding protein 1; nasopharyngeal carcinoma-associated antigen 13; heat shock factor binding protein 1; Nasopharyngeal carcinoma-associated antigen 13; NPC-A-13

HSBP-1

HSBP1; HSBP1; NPC-A-13; HSF1BP; NPC-A-13

HSBP1_HUMAN

E Coli

76

MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK NIADLMTQAG VEELESENKI PATQKS.

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The HSBP1 protein (1mg/ml) solution contains 20mM Tris-HCl buffer pH-7.5, 50mM NaCl, 1mM EDTA and 20% Glycerol. Sterile filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

HEAT SHOCK PROTEINS; Recombinant Proteins; Heat Shock Protein

Description: Recombinant Human HSBP1 produced in E Coli is a single,non-glycosylated polypeptide chain containing 76 amino acids and having a molecular mass of 8.5 kDa. Introduction: The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein-1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.

4557647

NP_001528.1

NM_001537.3

O75506

8,544 Da

Attenuation Phase Pathway 1127556!!Cellular Response To Heat Stress Pathway 1127553!!Cellular Responses To Stress Pathway 645258!!HSF1 Activation Pathway 1127554!!HSF1-dependent Transactivation Pathway 1127555

The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]

0.01 mg

140 USD