protein

Thymosin-b4

MBS142668

1 mg

205 USD

Native Protein

Thymosin-b4

Thymosin-b4

Thymosin beta4; Thymosin beta4; Thymosin b4; Thymosin beta-4; T beta 4; Fx; TB4X; PTMB4; TMSB4; Thymosin beta4

thymosin beta-4; Thymosin beta-4; thymosin beta-4; prothymosin beta-4; t beta-4; thymosin, beta 4, X chromosome; thymosin beta 4, X-linked; FxHematopoietic system regulatory peptideAlternative name(s):Seraspenide

TMSB4X; TMSB4X; FX; TB4X; PTMB4; TMSB4; TB4X; THYB4; TMSB4; T beta-4

TYB4_HUMAN

44

Greater than 98.0% as determined by RP-HPLC.

The protein (1 mg/ml) was lyophilized with no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized Thymosin b4 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution T beta 4 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized Thymosin beta-4 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

HORMONES; Hormones; Thymosin

Description: Thymosin b4 is a 43 amino acid peptide which is regarded as the main intracellular G-actin sequestering peptide.It has a molecular weight of 4963.55 Da, and its molecular formula is: C212H350N56O78S1. Extracellular Thymosin b4 may contribute to physiological processes such as angiogenesis, wound healing, and regulation of inflammation. Thymosin b4 has an a.a. sequence of Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH. Introduction: Thymosin is a hormone secreted from the thymus. Its primary function is to stimulate the production of T cells, which are an important part of the immune system. Thymosin also assists in the development of B cells to plasma cells to produce antibodies. The predominant form of thymosin, thymosin b4, is a member of a highly conserved family of actin monomer-sequestering proteins. b-thymosins are the primary regulators of unpolymerized actin, and are essential for maintaining the small cytoplasmic pool of free G-actin monomers required for rapid filament elongation and allowing for the flux of monomers between the thymosin-bound pool and F-actin.

11056061

NP_066932.1

NM_021109.3

P62328

5,053 Da

Hemostasis Pathway (106028); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050); Regulation Of Actin Cytoskeleton Pathway (198874); Regulation Of Actin Cytoskeleton Pathway (83089); Regulation Of Actin Cytoskeleton Pathway (500); Response To Elevated Platelet Cytosolic Ca2+ Pathway (106048)

This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]

TMSB4X: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. Protein type: Cytoskeletal; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: Xq21.3-q22. Cellular Component: cytoskeleton; extracellular region. Molecular Function: actin monomer binding; protein binding. Biological Process: platelet activation; platelet degranulation; sequestering of actin monomers; actin filament organization; blood coagulation

1 mg

205 USD

5 mg

595

25 mg

1885