Human Leutenizing hormone Releasing Hormone (Gonadorelin) | MyBioSource MBS142655 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human Leutenizing hormone Releasing Hormone (Gonadorelin)

catalog :

MBS142655

quantity :

10 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142655

products type :

Native Protein

products full name :

Human Leutenizing hormone Releasing Hormone (Gonadorelin)

products short name :

Leutenizing hormone Releasing Hormone

products name syn :

LHRH Human; Luteinizing Hormone Releasing Hormone Human; Progonadoliberin-1; Progonadoliberin I; LHRH; GRH; GNRH; LNRH

other names :

progonadoliberin-1 isoform 2 preproprotein; Progonadoliberin-1; progonadoliberin-1; GnRH-associated peptide 1; gonadotropin-releasing hormone 1 (leutinizing-releasing hormone); luliberin I; progonadoliberin I; prolactin release-inhibiting factor; gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Progonadoliberin ICleaved into the following 2 chains:Gonadoliberin-1Alternative name(s):Gonadoliberin I; Gonadorelin; Gonadotropin-releasing hormone I; GnRH-I; Luliberin I; Luteinizing hormone-releasing hormone I; LH-RH I

products gene name :

LHRH

other gene names :

GNRH1; GNRH1; GRH; GNRH; HH12; LHRH; LNRH; GNRH; GRH; LHRH; GnRH-I; LH-RH I

uniprot entry name :

GON1_HUMAN

sequence length :

sequence :

Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2.

purity :

Greater than 98.0% as determined by RP-HPLC.

form :

The LHRH was lyophilized from a concentrated (1 mg/ml) solution with no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized LHRH although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution LNRH should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized LHRH in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. The LHRH is also soluble in a 1% glacial acetic acid.

products categories :

HORMONES; Hormones; LHRH

products description :

Description: Lutenizing Hormone Releasing Hormone Human Synthetic is a single, non-glycosylated, polypeptide chain containing 10 amino acids and having a molecular mass of 1182. 3 Dalton. The molecular formula is C55H75N17O13. The CAS Number is 71447-49-9. Introduction: Gonadotropin-releasing hormone 1 (GNRH1), also known as Luteinising-hormone releasing hormone (LHRH), is a peptide hormone responsible for the release of FSH and LH from the anterior pituitary. GNRH1 is synthesized and released by the hypothalamus.At the pituitary, GNRH1 stimulates the synthesis and secretion of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These processes are controlled by the size and frequency of GNRH1 pulses, as well as by feedback from androgens and estrogens. Low requency GNRH1 pulses lead to FSH release, whereas high frequency GNRH1 pulses stimulate LH release.There are differences in GNRH1 secretion between males and females. In males, GNRH1 is secreted in pulses at a constant frequency, but in females the frequency of the pulses varies during the menstrual cycle and there is a large surge of GNRH1 just before ovulation.GNRH1 secretion is pulsatile in all vertebrates, and is necessary for correct reproductive function. Thus, a single hormone, GNRH1, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male.

ncbi gi num :

133908612

ncbi acc num :

NP_001076580.1

ncbi gb acc num :

NM_001083111.1

uniprot acc num :

P01148

ncbi mol weight :

10,380 Da

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); GnRH Signaling Pathway (83091); GnRH Signaling Pathway (502); Hormone Ligand-binding Receptors Pathway (106369)

ncbi summary :

The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide 1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2012]

uniprot summary :

GNRH1: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. Belongs to the GnRH family. Protein type: Hormone; Cell cycle regulation; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 8p21-p11.2. Cellular Component: extracellular space; extracellular region. Molecular Function: hormone activity; luteinizing hormone-releasing factor activity. Biological Process: negative regulation of cell proliferation; ovulation cycle; response to ethanol; cell-cell signaling; regulation of gene expression; multicellular organismal development; female pregnancy; signal transduction; negative regulation of apoptosis; response to corticosteroid stimulus. Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia

size1 :

10 mg

price1 :

140 USD

size2 :

25 mg

price2 :

195

size3 :

100 mg

price3 :

380

more info or order :

MyBioSource product webpage