catalog number :
MBS142644
products type :
Native Protein
products full name :
Human Chorionic Gonadotropin
products short name :
Chorionic Gonadotropin
products name syn :
hCG; Chorionic Gonadotropin Human; Chorionic gonadotropin; hCG; CG
other names :
choriogonadotropin subunit beta; Choriogonadotropin subunit beta; choriogonadotropin subunit beta; CG-beta; chorionic gonadotrophin chain beta; chorionic gonadotropin beta 3 subunit; chorionic gonadotropin beta chain; chorionic gonadotropin beta subunit; chorionic gonadotropin, beta polypeptide; Chorionic gonadotrophin chain beta
other gene names :
CGB; CGB; CGB3; CGB5; CGB7; CGB8; hCGB; CGB3; CG-beta
uniprot entry name :
CGHB_HUMAN
host :
Urine of pregnant women
form :
The hCG was lyophilized with no additives. Sterile Filtered White lyophilized (freeze-dried) powder.
storage stability :
Lyophilized hCG although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CG-beta should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
other info1 :
Contaminents: Free of: HbsAg, Hepatitis B surface antigen and antibodies to HIV, Hepatitis C and HCV.
other info2 :
Solubility: It is recommended to reconstitute the lyophilized Human Chorionic Gonadotropin in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The activity was found to be 5018IU/mg.
products categories :
HORMONES; Hormones; HCG
products description :
Description: Human Chorionic Gonadotropin is produced from a sterile preparation of placental glucoprotein urine of pregnant women having a total molecular mass of 36,700 Dalton. The hCG consists of 237 amino acids, a chain-92 amino acids and b chain-145 amino acids. The hCG is purified by proprietary chromatographic techniques. Introduction: Human chorionic gonadotropin (hCG) is a peptide hormone produced in pregnancy, that is made by the embryosoon after conception and later by the syncytiotrophoblast(part of the placenta). Its role is to prevent the disintegration of the corpus luteumof the ovaryand thereby maintain progesterone production that is critical for a pregnancy in humans. hCG may have additional functions, for instance it is thought that it affects the immune tolerance of the pregnancy. Early pregnancy testing generally is based on the detection or measurement of hCG.
ncbi acc num :
NP_000728.1
ncbi gb acc num :
NM_000737.3
ncbi mol weight :
19,053 Da
ncbi pathways :
Glycoprotein Hormones Pathway (160989); Metabolism Of Proteins Pathway (106230); Peptide Hormone Biosynthesis Pathway (160988); Peptide Hormone Metabolism Pathway (771603)
ncbi summary :
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
uniprot summary :
CGB: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. Belongs to the glycoprotein hormones subunit beta family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Inhibitor; Secreted. Chromosomal Location of Human Ortholog: 19q13.32. Cellular Component: extracellular region. Molecular Function: hormone activity. Biological Process: cellular protein metabolic process; cell-cell signaling; apoptosis; peptide hormone processing; female gamete generation; signal transduction