protein

Recombinant HIV-1 pol Integrase

MBS142609

0.1 mg

225 USD

Recombinant Protein

Recombinant HIV-1 pol Integrase

HIV-1 pol Integrase

HIV-1 Integrase; HIV-1 Integrase Recombinant; HIV-1 Integrase

E Coli

mfldgidkaqeehekyhsnwramasdfnlppvvakeiva
scdkcqlkgeamhgqvdcspgiwqldcthlegkvilvav
hvasgyieaevipaetgqetayfilklagrwpvktihtd
ngsnftsttvkaacwwagikqefgipynpqsqgviesmn
kelkkiigqvrdqaehlktavqmavfihnfkrkggiggy
sagerivdiiatdiqtkelqkqitkiqnfrvyyrdsrdp
lwkgpakllwkgegavviqdnsdikvvprrkakiirdyg
kqmagddcvasrqdedhhhhhh.

Immunoreactive with all sera of HIV-1 infected individuals.

Greater than 95.0% as determined by SDS-PAGE.

1.5M urea, 25mM Tris-HCl pH 8.0, 0.2% Triton-X & 50% Glycerol. Sterile filtered colorless clear solution.

4.55mg/1ml

ELISA (EIA), Western Blot (WB)

HIV-1 Integrase antigen is suitable for ELISA and Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems.

VIRAL ANTIGENS- HUMAN IMMUNODEFICIENCY VIRUS; Viral Antigens; HIV

Description: The E Coli derived 36 kDa recombinant protein is a non-glycosylated polypeptide chain, containing the HIV-1 immunodominant regions from the pol protein (intergrase) and fused with a six histidines tag. Introduction: Integrase is an enzyme produced by the HIV which enables its genetic material to be integrated into the DNA of the infected cell and is a key component in the pre-integration complex. HIV integrase contains 3 domains, an N-terminal HH-CC zinc fingerdomainwhich is partially responsible for multimerization, a central catalytic domain and a C-terminal domain. Both Central catalytic domain and C-terminal domains have been shown to bind both viral and cellular DNA. No crystal structure data exists with Integrase bound to its DNA substrates. HIV-1 integrase functions as a dimeror a tetramer. Additionally, several host cellular proteins interact with integrase and may facilitate the integration process.

0.1 mg

225 USD

0.5 mg

645

1 mg

1220