catalog number :
MBS142556
products type :
Recombinant Protein
products full name :
Recombinant Hepatitis C Virus Nucleocapsid (core) 22kDa
products short name :
Hepatitis C Virus Nucleocapsid
products name syn :
HCV Core 22kDa; Hepatitis C Virus Core 22kDa Recombinant; HCV 22kDa
other names :
hepatitis C virus polyprotein; Genome polyprotein
uniprot entry name :
D5MTP0_9HEPC
sequence :
mstnpkpqrk tkrntnrrpq dvkfpgvgqi vggvyllprr gprlgvratr ktsersqprg rrqpipkarr pegrtwaqpg ypwplygneg cgwagwllsp rgsrpswgpt dprrrsrnlg kvidtltcgf adlmgyiplv gaplggaara lahgvrvled gvnyatgnlp gcsfsiflla llscltvpa.
specificity :
Immunoreactive with sera of HCV-infected individuals.
purity :
HCV-Core Protein is >95% pure as determined by 10% PAGE (coomassie staining). HCV-Core protein was purified by proprietary chromatographic technique.
form :
20mM Tris Hcl pH-8, 8M urea and 10mM b-mercaptoethanol.
products categories :
VIRAL ANTIGENS- HEPATITIS C VIRUS; Viral Antigens; Hepatitis C
products description :
Description: The E Coli derived recombinant protein contains the HCV core nucleocapsid genotype 1b, immunodominant regions, amino acids 2-192, 22kDa.The protein is fused with b-galactosidase (114 kDa) at N-terminus. Introduction: HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus in the family Flaviviridae. HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes(1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6).
ncbi acc num :
BAJ07247.1
ncbi mol weight :
330,337 Da