catalog number :
MBS142513
products type :
Recombinant Protein
products full name :
Recombinant Hepatitis B Virus Core (1-183)
products short name :
Hepatitis B Virus Core
products name syn :
HBV core (1-183 a.a.); Hepatitis B Virus Core (1-183 a.a.) Recombinant
other names :
HBcAg; HBcAg; HBcAg
products gene name :
HBcAg
uniprot entry name :
Q00K45_HBV
specificity :
Immunoreactive with sera HBV-infected individuals.
purity :
HBV Core protein is >95% pure as determined by SDS-PAGE. HBV Core protein was purified by proprietary chromatographic technique.
form :
(1mg/ml)7.5mM phosphate buffer pH-7.2, 75mM NaCl and 50% glycerol.
storage stability :
HBV Core protein although stable at 4 degree C for 1 week, should be stored below -18 degree C. Please prevent freeze thaw cycles.
products categories :
VIRAL ANTIGENS- HEPATITIS B VIRUS; Viral Antigens; Hepatitis B
products description :
Description: The E Coli derived 18 kDa recombinant protein contains the HBV core ayw immunodominant region, amino acids 1-183. Introduction: Hepatitis B is one of a few known non-retroviralviruses which employ reverse transcriptionas a part of its replication process. (HIV, a completely unrelated virus, also uses reverse transcription, but it is a retrovirus.) HBV invades the cell by binding to surface receptor and become internalized. The viral core particles then migrate to the hepatocyte nucleus and the partially double-stranded, relaxed circular genomes (RC-DNA) are repaired to form a covalently closed circular DNA (cccDNA), which is the template for viral genomic and sub-genomic RNAs by cellular RNA polymerase II. Of these, the pregenomic RNA (pgRNA is selectively packaged into progeny capsids and is then reverse-transcribed into new RC-DNA. The core can either bud into the endoplasmic reticulum to be enveloped or exported from the cell or recycled back into the genome for conversion to cccDNA.
ncbi acc num :
ABE97049.1
ncbi mol weight :
21,033 Da