protein

Recombinant Hepatitis B Virus Core (1-186)

MBS142511

0.1 mg

225 USD

Recombinant Protein

Recombinant Hepatitis B Virus Core (1-186)

Hepatitis B Virus Core

HBV core (1-186 a.a.); Hepatitis B Virus Core (1-186 a.a.) Recombinant

HBcAg; HBcAg; HBcAg

HBcAg

Q00K45_HBV

183

Immunoreactive with sera HBV-infected individuals.

HBV Core protein is >90% pure as determined by 10% PAGE (Coomassie staining). HBV Core protein was purified by proprietary chromatographic technique.

25mM Tris-HCl pH-8.0, 1.5mM Urea & 50% glycerol.

VIRAL ANTIGENS- HEPATITIS B VIRUS; Viral Antigens; Hepatitis B

Description: The E Coli derived recombinant protein contains the HBV core immunodominant region amino acids 1-186, and fused to a His tag at N- terminus. Introduction: Hepatitis B is one of a few known non-retroviralviruses which employ reverse transcriptionas a part of its replication process. (HIV, a completely unrelated virus, also uses reverse transcription, but it is a retrovirus.) HBV invades the cell by binding to surface receptor and become internalized. The viral core particles then migrate to the hepatocyte nucleus and the partially double-stranded, relaxed circular genomes (RC-DNA) are repaired to form a covalently closed circular DNA (cccDNA), which is the template for viral genomic and sub-genomic RNAs by cellular RNA polymerase II. Of these, the pregenomic RNA(pgRNA is selectively packaged into progeny capsids and is then reverse-transcribed into new RC-DNA. The core can either bud into the endoplasmic reticulum to be enveloped or exported from the cell or recycled back into the genome for conversion to cccDNA.

93004257

ABE97049.1

21,033 Da

0.1 mg

225 USD

0.5 mg

645

1 mg

1030