Recombinant Human Ubiquitin Conjugating Enzyme E2L 6 | MyBioSource MBS142488 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Ubiquitin Conjugating Enzyme E2L 6

catalog :

MBS142488

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142488

products type :

Recombinant Protein

products full name :

Recombinant Human Ubiquitin Conjugating Enzyme E2L 6

products short name :

Ubiquitin Conjugating Enzyme E2L 6

products name syn :

UBE2L6 Human; Ubiquitin Conjugating Enzyme E2L 6 Human Recombinant; RIG-B; UBCH8; MGC40331; UBE2L6; Ubiquitin/ISG15-conjugating enzyme E2 L6; Ubiquitin-protein ligase L6; Ubiquitin carrier protein L6; Retinoic acid-induced gene B protein

other names :

ubiquitin/ISG15-conjugating enzyme E2 L6 isoform 1; Ubiquitin/ISG15-conjugating enzyme E2 L6; ubiquitin/ISG15-conjugating enzyme E2 L6; retinoic acid induced gene B protein; retinoic acid-induced gene B protein; ubiquitin carrier protein L6; ubiquitin-protein ligase L6; ubiquitin-conjugating enzyme E2L 6; Retinoic acid-induced gene B protein; RIG-B; UbcH8; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6

products gene name :

UBE2L6

other gene names :

UBE2L6; UBE2L6; RIG-B; UBCH8; UBCH8; RIG-B

uniprot entry name :

UB2L6_HUMAN

host :

E Coli

sequence length :

153

sequence :

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMASM RVVKELEDLQ KKPPPYLRNL SSDDANVLVW HALLLPDQPP YHLKAFNLRI SFPPEYPFKP PMIKFTTKIY HPNVDENGQI CLPIISSENW KPCTKTCQVL EALNVLVNRP NIREPLRMDL ADLLTQNPEL FRKNAEEFTL RFGVDRPS.

purity :

Greater than 90% as determined by SDS-PAGE.

form :

The protein contains 20mM Tris pH-8, 0.1mM PMSF, 1mM DTT, and 10% glycerol. Sterile filtered colorless solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

products categories :

ENZYMES; Enzymes; Ubiquitin Conjugating Enzyme

products description :

Description: UBE2L6 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 188 amino acids (1-152 a.a.) & having a molecular mass of 21.7 kDa. The UBE2L6 is fused to a 36 amino acid His Tag at N-terminus and purified by standard chromatography techniques. Introduction: UBE2L6 belongs to the E2 ubiquitin-conjugating enzyme family. UBE2L6 enzyme is very similar in its primary structure to the enzyme encoded by UBE2L3 gene. UBE2L6 catalyzes the covalent attachment of ubiquitin to other proteins. UBE2L6 functions in the e6/e6-ap-induced ubiquitination of p53/tp53.

ncbi gi num :

4759282

ncbi acc num :

NP_004214.1

ncbi gb acc num :

NM_004223.4

uniprot acc num :

O14933

ncbi mol weight :

10,086 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Antigen Processing: Ubiquitination Proteasome Degradation Pathway (366162); Antiviral Mechanism By IFN-stimulated Genes Pathway (530760); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Cytokine Signaling In Immune System Pathway (366171); ISG15 Antiviral Mechanism Pathway (530761); Immune System Pathway (106386); Innate Immune System Pathway (106387); Interferon Signaling Pathway (187103); Negative Regulators Of RIG-I/MDA5 Signaling Pathway (187102)

ncbi summary :

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

uniprot summary :

UBE2L6: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. Belongs to the ubiquitin-conjugating enzyme family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Ligase; Ubiquitin conjugating system; EC 6.3.2.19; Ubiquitin ligase. Chromosomal Location of Human Ortholog: 11q12. Cellular Component: cytosol. Molecular Function: protein binding; ISG15 conjugating enzyme activity; ubiquitin-protein ligase activity; ligase activity. Biological Process: ISG15-protein conjugation; modification-dependent protein catabolic process; cytokine and chemokine mediated signaling pathway; innate immune response; protein ubiquitination; protein modification process; negative regulation of interferon type I production

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.025 mg

price2 :

205

size3 :

1 mg

price3 :

3490

more info or order :

MyBioSource product webpage