protein

Recombinant Human Ubiquitin Conjugating Enzyme E2C

MBS142487

0.02 mg

205 USD

Recombinant Protein

Recombinant Human Ubiquitin Conjugating Enzyme E2C

Ubiquitin Conjugating Enzyme E2C

UBE2C Human; Ubiquitin Conjugating enzyme E2C Human Recombinant; Ubiquitin-conjugating enzyme E2 C; EC 6.3.2.19; Ubiquitin-protein ligase C; Ubiquitin carrier protein C; Ubc10; UBCH10; dJ447F3.2

ubiquitin-conjugating enzyme E2 C isoform 6; Ubiquitin-conjugating enzyme E2 C; ubiquitin-conjugating enzyme E2 C; cyclin-selective ubiquitin carrier protein; mitotic-specific ubiquitin-conjugating enzyme; ubiquitin-protein ligase C; ubiquitin-conjugating enzyme E2C; UbcH10; Ubiquitin carrier protein C; Ubiquitin-protein ligase C

UBE2C

UBE2C; UBE2C; UBCH10; dJ447F3.2; UBCH10

UBE2C_HUMAN

E Coli

132

Greater than 90.0% as determined by Analysis by SDS-PAGE.

UBE2C protein 1mg/ml is supplied in 20mM Tris-HCL, pH-8, 0.15M NaCl, 1mM DTT and 10% Glycerol. Sterile Filtered clear solution.

ENZYMES; Enzymes; Ubiquitin Conjugating Enzyme

Description: UBE2C Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 202 amino acids (1-179) and having a molecular mass of 22.1 kDa.The UBE2C is fused to a 23 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: UbcH10 is an essential mediator of mitotic destruction events and cell cycle progression. It catalyzes the destruction of cyclins A and B in conjunction with the anaphase-promoting complex, and therefore, plays an important role in the control of the cell exit from mitosis This activity is essential at then end of mitosis for the inactivation of their partner kinase Cdc2 and exit from mitosis into G1 of the next cell cycle. In addition, UbcH10 bears homology to yeast PAS2, a gene that is essential for biogenesis of peroxisomes. UbcH10 is useful for in vitro ubiquitinylation reactions.

528524529

NP_001268670.1

NM_001281741.1

O00762

17,373 Da

APC-Cdc20 Mediated Degradation Of Nek2A Pathway 1127551!!APC/C-mediated Degradation Of Cell Cycle Proteins Pathway 105825!!APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway 105832!!APC/C:Cdc20 Mediated Degradation Of Securin Pathway 105833!!APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway 105831!!APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway 105835!!APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway 1127549!!Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway 105829!!Adaptive Immune System Pathway 366160!!Antigen Processing: Ubiquitination Proteasome Degradation Pathway 366162

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]

0.02 mg

205 USD