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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Ubiquitin-Conjugating Enzyme E2L 3
catalog :
MBS142483
quantity :
0.01 mg
price :
140 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS142483
products type :
Recombinant Protein
products full name :
Recombinant Human Ubiquitin-Conjugating Enzyme E2L 3
products short name :
Ubiquitin-Conjugating Enzyme E2L 3
products name syn :
UBE2L3 Human; Ubiquitin-Conjugating Enzyme E2L 3 Human Recombinant; Ubiquitin-conjugating enzyme E2 L3; EC 6.3.2.19; Ubiquitin-protein ligase L3; Ubiquitin carrier protein L3; UbcH7; E2-F1; L-UBC; UbcM4
other names :
ubiquitin-conjugating enzyme E2 L3 isoform 4; Ubiquitin-conjugating enzyme E2 L3; ubiquitin-conjugating enzyme E2 L3; ubiquitin carrier protein L3; ubiquitin-conjugating enzyme E2-F1; ubiquitin-conjugating enzyme UBCH7; ubiquitin-protein ligase L3; ubiquitin-conjugating enzyme E2L 3; L-UBC; UbcH7; Ubiquitin carrier protein L3; Ubiquitin-conjugating enzyme E2-F1; Ubiquitin-protein ligase L3
products gene name :
UBE2L3
other gene names :
UBE2L3; UBE2L3; E2-F1; L-UBC; UBCH7; UbcM4; UBCE7; UBCH7
uniprot entry name :
UB2L3_HUMAN
host :
E Coli
sequence length :
212
sequence :
MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA FRIEINFPAE YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQVIQSLIA LVNDPQPEHP LRADLAEEYS KDRKKFCKNA EEFTKKYGEK RPVD.
purity :
Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
The protein contains 50mM HEPES (pH-7.5) 150mM NaCl, 1mM DTT, and 10% glycerol. Sterile filtered colorless solution.
storage stability :
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
products categories :
ENZYMES; Enzymes; Ubiquitin Conjugating Enzyme
products description :
Description: Ubiquitin-Conjugating Enzyme E2L 3 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 154 amino acids & having a molecular mass of 17.9 kDa. Introduction: Human Ubquitin-conjugating enzyme 7 (UbcH7) is a ubiquitin-conjugating enzyme (E2) mediating c-fos degradation, transcription factor NF-B maturation, and human papilloma virus-mediated p53 and Myc protein degradation, in vitro. The ubiquitin-conjugating enzymes (E2s) are essential components of the post-translational protein ubiquitination pathway, mediating the transfer of activated ubiquitin to substrate proteins. The human UBE2L1-UBE2L4 gene could potentially encode different isoforms of the UbcH7. UBE2L3 gene, located at chromosome 22q11.2, is the only identical family member with introns and encodes a polypeptide sequence identical to that of UbcH7.
ncbi gi num :
373432684
ncbi acc num :
NP_001243284.1
ncbi gb acc num :
NM_001256355.1
uniprot acc num :
P68036
ncbi mol weight :
24,004 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Alpha-synuclein Signaling Pathway 137913!!Antigen Processing: Ubiquitination Proteasome Degradation Pathway 366162!!BARD1 Signaling Events Pathway 137959!!Class I MHC Mediated Antigen Processing Presentation Pathway 366161!!Immune System Pathway 106386!!Parkin-Ubiquitin Proteasomal System Pathway 700638!!Parkinson's Disease Pathway 83098!!Parkinsons Disease Pathway 705377!!Ubiquitin Mediated Proteolysis Pathway 83056
ncbi summary :
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
size :
0.01 mg
price :
140 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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