Recombinant Human Placental Alkaline Phosphatase | MyBioSource MBS142474 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Placental Alkaline Phosphatase

catalog :

MBS142474

quantity :

0.002 mg

price :

265 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142474

products type :

Recombinant Protein

products full name :

Recombinant Human Placental Alkaline Phosphatase

products short name :

Placental Alkaline Phosphatase

products name syn :

PLAP Human; Placental Alkaline Phosphatase Human Recombinant; ALP; PLAP; Alkaline phosphatase placental type; EC 3.1.3.1; PLAP-1; Alkaline phosphatase Regan isozyme

other names :

alkaline phosphatase, placental type preproprotein; Alkaline phosphatase, placental type; alkaline phosphatase, placental type; alkaline phosphatase Regan isozyme; alkaline phosphomonoesterase; glycerophosphatase; placental alkaline phosphatase 1; alkaline phosphatase, placental; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1

products gene name :

PLAP

other gene names :

ALPP; ALPP; ALP; PALP; PLAP; PLAP-1; PLAP; PLAP-1

uniprot entry name :

PPB1_HUMAN

host :

E Coli

sequence length :

535

form :

PLAP in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol. Sterile filtered liquid.

concentration :

100ug/ml

storage stability :

Store vial at -20 degree C to -80 degree C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.

products categories :

ENZYMES; Enzymes; Phosphatase

products description :

Description: Placental Alkaline Phosphatase Human Recombinant encoding 154-287 amino acids expressed in E Coli, shows a 41kDa band on SDS-PAGE (including GST tag).PLAP Human Recombinant is purified by proprietary chromatographic techniques. Introduction: Placental alkaline phosphatase (PLAP) is a membrane-associated siaglycoprotein enzyme normally present at high concentration in syncytiotrophoblasts within the placenta during the third trimester of gestation. The expression of PLAP was originally thought to be restricted to term placenta but a human PLAP-like variant has been described which shares more than 85% homology with PLAP itself. PLAP is expressed only in normal term placenta, endocervix and fallopian tube and also in ovarian and proximal gastrointestinal tumors. It is also commonly expressed in germ cell tumors and more recently described in seminomas.

ncbi gi num :

94721246

ncbi acc num :

NP_001623.3

ncbi gb acc num :

NM_001632.4

uniprot acc num :

P05187

ncbi mol weight :

57,954 Da

ncbi pathways :

Folate Biosynthesis Pathway (83018); Folate Biosynthesis Pathway (404); Metabolic Pathways (132956); Pyridoxal 5'-phosphate Salvage Pathway (142237)

ncbi summary :

The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]

uniprot summary :

ALPP: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3 untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]. Protein type: Membrane protein, GPI anchor; Phosphatase (non-protein); Motility/polarity/chemotaxis; EC 3.1.3.1; Cell surface; Cofactor and Vitamin Metabolism - folate biosynthesis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q37. Cellular Component: cell surface; plasma membrane; integral to membrane. Molecular Function: alkaline phosphatase activity; zinc ion binding; magnesium ion binding. Biological Process: dephosphorylation

size1 :

0.002 mg

price1 :

265 USD

size2 :

0.005 mg

price2 :

365

size3 :

0.01 mg

price3 :

610

more info or order :

MyBioSource product webpage