protein

Recombinant Human Methionine Adenosyltransferase II, Alpha

MBS142461

0.02 mg

205 USD

Native Protein

Recombinant Human Methionine Adenosyltransferase II, Alpha

Methionine Adenosyltransferase II, Alpha

MAT2A Human; Methionine Adenosyltransferase II Alpha Human Recombinant; MATA2; MATII; SAMS2; MAT-2A; S-adenosylmethionine synthetase isoform type-2; AdoMet synthetase 2; Methionine adenosyltransferase 2; Methionine adenosyltransferase II; MAT2A; AMS2

S-adenosylmethionine synthase isoform type-2; S-adenosylmethionine synthase isoform type-2; S-adenosylmethionine synthase isoform type-2; MAT 2; MAT-II; adoMet synthase 2; adoMet synthetase 2; methionine adenosyltransferase 2; methionine adenosyltransferase II, alpha; Methionine adenosyltransferase 2; MAT 2; Methionine adenosyltransferase II; MAT-II

MAT2A

MAT2A; MAT2A; MATA2; MATII; SAMS2; AMS2; MATA2; AdoMet synthase 2; MAT 2; MAT-II

METK2_HUMAN

E Coli

395

MGSSHHHHHH SSGLVPRGSH MNGQLNGFHE AFIEEGTFLF TSESVGEGHP DKICDQISDA VLDAHLQQDP DAKVACETVA KTGMILLAGE ITSRAAVDYQ KVVREAVKHI GYDDSSKGFD YKTCNVLVAL EQQSPDIAQG VHLDRNEEDI GAGDQGLMFG YATDETEECM PLTIVLAHKL NAKLAELRRN GTLPWLRPDS KTQVTVQYMQ DRGAVLPIRV HTIVISVQHD EEVCLDEMRD ALKEKVIKAV VPAKYLDEDT IYHLQPSGRF VIGGPQGDAG LTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW VAKSLVKGGL CRRVLVQVSY AIGVSHPLSI SIFHYGTSQK SERELLEIVK KNFDLRPGVI VRDLDLKKPI YQRTAAYGHF GRDSFPWEVP KKLKY.

Greater than 95.0% as determined by SDS-PAGE.

The MAT2A solution (1mg/ml) contains 20mM Tris pH-8 & 10% glycerol. Sterile Filtered colorless solution.

MAT2A although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

ENZYMES; Enzymes; Transferase

Description: MAT2A Human Recombinant fused with His tag (20 a.a.) at C-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 415 amino acids and having a molecular mass of 45.8 kDa.The MAT2A is purified by proprietary chromatographic techniques. Introduction: MAT2A is an important enzyme in cellular metabolism and catalyzes the formation of S-adenosylmethionine (SAMe) from L-methionine and ATP. MAT2A is expressed in extrahepatic tissues. In liver, MAT2A expression associates with growth, dedifferentiation, and cancer. NF-kappa B and AP-1 are necessary for basal MAT2A expression in HepG2 cells and mediate the increase in MAT2A expression in response to TNF-alpha. Up-regulation of MAT2A provides growth improvement and s-adenosylmethionine and methylthioadenosine thus can block mitogenic signaling in colon cancer cells. Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells.

5174529

NP_005902.1

NM_005911.5

P31153

32,965 Da

Biological Oxidations Pathway 105698!!Biosynthesis Of Amino Acids Pathway 790012!!Biosynthesis Of Amino Acids Pathway 795174!!C-MYB Transcription Factor Network Pathway 138073!!Cysteine And Methionine Metabolism Pathway 104488!!Cysteine And Methionine Metabolism Pathway 103421!!Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway 1127639!!Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway 1127658!!Defective GGT1 Causes Glutathionuria (GLUTH) Pathway 1127659!!Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway 1127660

The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]

0.02 mg

205 USD