Recombinant Human Set7/9 Histone Methyltransferase | MyBioSource MBS142455 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Set7/9 Histone Methyltransferase

catalog :

MBS142455

quantity :

0.02 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142455

products type :

Recombinant Protein

products full name :

Recombinant Human Set7/9 Histone Methyltransferase

products short name :

Set7/9 Histone Methyltransferase

products name syn :

SETD7 Human; Set7/9 Histone Methyltransferase Human Recombinant; Histone-lysine N-methyltransferase; H3 lysine-4 specific SET7; EC 2.1.1.43; Histone H3-K4 methyltransferase; H3-K4-HMTase; SET domain-containing protein 7; Set9; SET7/9; SETD7

other names :

histone-lysine N-methyltransferase SETD7; Histone-lysine N-methyltransferase SETD7; histone-lysine N-methyltransferase SETD7; H3-K4-HMTase SETD7; SET domain-containing protein 7; histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; lysine N-methyltransferase 7; SET domain containing (lysine methyltransferase) 7; Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9

products gene name :

SETD7

other gene names :

SETD7; SETD7; KMT7; SET7; SET9; SET7/9; KIAA1717; KMT7; SET7; SET9; H3-K4-HMTase SETD7

uniprot entry name :

SETD7_HUMAN

host :

E Coli

sequence length :

366

sequence :

MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGNSV YHFDKSTSSC ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP EWYQVELKAF QATQQK

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The protein containing 50mM Tris-HCl buffer (pH7.5), 0.2M NaCl, 5mM DTT and 20% glycerol. Sterile Filtered clear soultion.

storage stability :

Store at 4 degree C if entire vial will be used within 1-2 weeks. Store, frozen at -20 degree C for longer periods of time.Please prevent freeze-thaw cycles.

products categories :

ENZYMES; Enzymes; Transferase

products description :

Description: SETD7 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 366 amino acids & having a molecular mass of 40.7 kDa. The SETD7 purified by proprietary chromatographic techniques. Introduction: Set 7/9 is a histone methyltransferase (HMTase) that transfers methyl groups to Lys4 of histone H3, in complex with S-adenosyl-L-methionine (AdoMet). The methylation of lysine residues of histones plays a critical role in the regulation of chromatin structure and gene expression. Acetylation, phosphorylation and methylation of the amino-terminal tails of histone are thought to be involved in the regulation of chromatin structure and function. The enzymes identified in the methylation of specific lysine residue on histones belong to the SET family with just one exception. Set7/9, unlike most other SET proteins, is exclusively a mono-methylase.

ncbi gi num :

18139549

ncbi acc num :

NP_085151.1

ncbi gb acc num :

NM_030648.2

uniprot acc num :

Q8WTS6

ncbi mol weight :

40,721 Da

ncbi pathways :

Chromatin Modifying Enzymes Pathway (1127682); Chromatin Organization Pathway (1127681); FoxO Signaling Pathway (921162); Lysine Degradation Pathway (82956); Lysine Degradation Pathway (320); PKMTs Methylate Histone Lysines Pathway (1127686); P53 Pathway (138067)

uniprot summary :

SETD7: Histone methyltransferase that specifically monomethylates Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates Lys-189 of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Interacts with IPF1/PDX-1. Widely expressed. Expressed in pancreatic islets. Belongs to the histone-lysine methyltransferase family. SET7 subfamily. Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase, protein lysine; Methyltransferase. Chromosomal Location of Human Ortholog: 4q28. Cellular Component: nucleoplasm; nucleolus; chromosome. Molecular Function: protein binding; p53 binding; protein-lysine N-methyltransferase activity; histone-lysine N-methyltransferase activity. Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of transcription, DNA-dependent; peptidyl-lysine di-methylation; peptidyl-lysine mono-methylation; chromatin modification; response to DNA damage stimulus

size1 :

0.02 mg

price1 :

140 USD

size2 :

0.1 mg

price2 :

205

size3 :

1 mg

price3 :

1030

more info or order :

MyBioSource product webpage