product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Threonyl t-RNA Synthetase
catalog :
MBS142445
quantity :
0.005 mg
price :
140 USD
more info or order :
product information
catalog number :
MBS142445
products type :
Recombinant Protein
products full name :
Recombinant Human Threonyl t-RNA Synthetase
products short name :
Threonyl t-RNA Synthetase
products name syn :
PL 7 Human; Threonyl-tRNA Synthetase Human Recombinant; Threonyl-tRNA synthetase cytoplasmic; EC 6.1.1.3; Threonine-tRNA ligase; ThrRS; MGC9344; PL-7; TARS
other names :
threonine--tRNA ligase, cytoplasmic isoform 1; Threonine--tRNA ligase, cytoplasmic; threonine--tRNA ligase, cytoplasmic; threonine tRNA ligase 1, cytoplasmic; threonyl-tRNA synthetase, cytoplasmic; threonyl-tRNA synthetase; Threonyl-tRNA synthetase; ThrRS
products gene name :
PL 7
other gene names :
TARS; TARS; ThrRS; ThrRS
uniprot entry name :
SYTC_HUMAN
host :
Sf9 Insect Cells
sequence length :
723
purity :
Greater than 90% as determined by SDS-PAGE.
form :
PL-7 is supplied in 20mM HEPES buffer pH-8, 200mM sodium chloride, and 20% glycerol. Sterile Filtered clear solution.
concentration :
0.3-0.8 ug/ml (depending on the type of ELISA plate and coating buffer).Suitable for biotinylation and iodination.
storage stability :
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.
other info2 :
Immunological Functions: 1. Binds IgG-type human auto-antibodies.2. Standard ELISA test (checker-board analysis of positive/negative sera panels immuno-dot test).
products categories :
ENZYMES; Enzymes; Synthetase
products description :
Description: Threonyl-tRNA Synthetase Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 83,312 Dalton. PL-7 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques. Introduction: Threonyl-tRNA Synthetase is a member of the aminoacyl-tRNA synthetase family, key enzymes of protein biosynthesis which charge tRNA molecules with the respective amino acids. This 83 kDa protein is an autoantigen recognized by PL-7 antibodies which occur in a subset of patients with polymyositis and dermatomyositis. Preliminary data suggest that PL-7 antibodies (similar to Jo-1 antibodies) indicate an increased risk for lung involvement, but this needs to be confirmed for a larger number of cases.
ncbi gi num :
386642860
ncbi acc num :
NP_001245366.1
ncbi gb acc num :
NM_001258437.1
uniprot acc num :
P26639
ncbi mol weight :
86,861 Da
ncbi pathways :
Aminoacyl-tRNA Biosynthesis Pathway (83030); Aminoacyl-tRNA Biosynthesis Pathway (424); Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway (413439); Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway (468360); Cytosolic TRNA Aminoacylation Pathway (105981); Gene Expression Pathway (105937); TRNA Aminoacylation Pathway (105980)
ncbi summary :
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]
uniprot summary :
TARS: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]. Protein type: Ligase; EC 6.1.1.3; Translation. Chromosomal Location of Human Ortholog: 5p13.2. Cellular Component: cytoplasm; cytosol; actin cytoskeleton. Molecular Function: threonine-tRNA ligase activity; protein homodimerization activity; ATP binding. Biological Process: tRNA aminoacylation for protein translation; translation; threonyl-tRNA aminoacylation; gene expression
size1 :
0.005 mg
price1 :
140 USD
size2 :
0.02 mg
price2 :
205
size3 :
1 mg
price3 :
3735
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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