Recombinant Human Matrix Metalloproteinase-8 | MyBioSource MBS142442 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Matrix Metalloproteinase-8

catalog :

MBS142442

quantity :

1 Unit

price :

205 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142442

products type :

Recombinant Protein

products full name :

Recombinant Human Matrix Metalloproteinase-8

products short name :

Matrix Metalloproteinase-8

products name syn :

MMP 8 Human; Matrix Metalloproteinase-8 Human Recombinant; Neutrophil collagenase; EC 3.4.24.34; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; HNC; CLG1

other names :

neutrophil collagenase isoform 1 preproprotein; Neutrophil collagenase; neutrophil collagenase; PMN leukocyte collagenase; PMNL collagenase; collagenase 2; matrix metallopeptidase 8 (neutrophil collagenase); matrix metalloproteinase 8 (neutrophil collagenase); matrix metalloproteinase-8; matrix metallopeptidase 8; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL

products gene name :

MMP 8

other gene names :

MMP8; MMP8; HNC; CLG1; MMP-8; PMNL-CL; CLG1; MMP-8; PMNL-CL

uniprot entry name :

MMP8_HUMAN

host :

E Coli

sequence length :

467

purity :

Greater than 90% as determined by SDS-PAGE.

form :

The MMP-8 protein solution (100 units/ml) in 0.05M Tris-HCl buffer, pH 7.6, 0.2M NaCl, 5mM CaCl2, 0.0025% NaN3 and 0.1% BSA. Sterile Filtered clear solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.

app notes :

Used as a standard for analyzing mammalian collagenase activity.

other info2 :

Biological Activity: 100 units/ml after activation with APMA by solution assay method.One unit of collagenolytic activity is defined as the cleavage of 1 ug of collagen per minute by the solution method.

products categories :

ENZYMES; Enzymes; Matrix Metalloproteinase

products description :

Description: Matrix Metalloproteinase-8 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain having a molecular mass of 75 kDa.The MMP-8 is purified by proprietary chromatographic techniques. Introduction: Full-length recombinant human neutrophil pro-collagenase (MMP-8), latent form.Matrix metalloproteinase 8 (MMP-8), or neutrophil collagenase, degrades interstitial collagens, acting preferentially on collagen type I. Increased full-length MMP-8 protein was associated with infiltration into the skin of neutrophils, which are the major cell type that expresses MMP-8.MMP-8 is synthesized and stored in specific granules in neutrophil leukocytes. MMP-8 activity is therefore regulated by factors such as surface-bound ligands (IgG or complement components) that release it through degranulation.Once released and activated through proteolytic or oxidative mechanisms, MMP-8 plays a major role in the connective tissue turnover that accompanies inflammatory processes.

ncbi gi num :

4505221

ncbi acc num :

NP_002415.1

ncbi gb acc num :

NM_002424.2

uniprot acc num :

P22894

ncbi mol weight :

53,412 Da

ncbi pathways :

Activation Of Matrix Metalloproteinases Pathway (576264); Collagen Degradation Pathway (730309); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Matrix Metalloproteinases Pathway (198900)

ncbi summary :

This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

uniprot summary :

MMP8: Can degrade fibrillar type I, II, and III collagens. Belongs to the peptidase M10A family. Protein type: Secreted; EC 3.4.24.34; Protease; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 11q22.3. Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region. Molecular Function: zinc ion binding; serine-type endopeptidase activity; metalloendopeptidase activity; calcium ion binding. Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; proteolysis

size1 :

1 Unit

price1 :

205 USD

size2 :

2.5 Units

price2 :

305

size3 :

10 Units

price3 :

940

more info or order :

MyBioSource product webpage