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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Betaine-Homocysteine Methyltransferase
catalog :
MBS142433
quantity :
0.01 mg
price :
140 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS142433
products type :
Recombinant Protein
products full name :
Recombinant Human Betaine-Homocysteine Methyltransferase
products short name :
Betaine-Homocysteine Methyltransferase
products name syn :
BHMT Human; Betaine Homocysteine S-Methyltransferase Human Recombinant; BHMT; Betaine Homocysteine S-Methyltransferase 1; BHMT1
other names :
betaine--homocysteine S-methyltransferase 1; Betaine--homocysteine S-methyltransferase 1; betaine--homocysteine S-methyltransferase 1; epididymis secretory sperm binding protein Li 61p; betaine--homocysteine S-methyltransferase
products gene name :
BHMT
other gene names :
BHMT; BHMT; BHMT1; HEL-S-61p
uniprot entry name :
BHMT1_HUMAN
host :
E Coli
sequence length :
406
sequence :
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMPP VGGKKAKKGI LERLNAGEIV IGDGGFVFAL EKRGYVKAGP WTPEAAVEHP EAVRQLHREF LRAGSNVMQT FTFYASEDKL ENRGNYVLEK ISGQEVNEAA CDIARQVADE GDALVAGGVS QTPSYLSCKS ETEVKKVFLQ QLEVFMKKNV DFLIAEYFEH VEEAVWAVET LIASGKPVAA TMCIGPEGDL HGVPPGECAV RLVKAGASII GVNCHFDPTI SLKTVKLMKE GLEAARLKAH LMSQPLAYHT PDCNKQGFIDLPEFPFGLEP RVATRWDIQK YAREAYNLGV RYIGGCCGFE PYHIRAIAEE LAPERGFLPPASEKHGSWGS GLDMHTKPWV RARARKEYWE NLRIASGRPY NPSMSKPDGW GVTKGTAELM QQKEATTEQQ LKELFEKQKF KSQ.
purity :
Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
The BHMT solution contains 20mM Tris-HCl pH-7.5 and 20% glycerol. Sterile Filtered clear colorless solution 1 mg/ml.
storage stability :
BHMT Recombinant Human although stable at 4 degree C for 30 days, should be stored desiccated below -20 degree C for periods greater than 30 days. Please avoid freeze-thaw cycles.
products categories :
ENZYMES; Enzymes; Transferase
products description :
Description: Betaine Homocysteine S-Methyltransferase Human Recombinant fused to His Tag at N-terminal produced in E Coli is a single, non-glycosylated, polypeptide chain containing 443 amino acids (21-236) and having a molecular mass of 49.2 kDa. The BHMT is purified by proprietary chromatographic techniques. Introduction: Betaine-homocysteine methyltransferase (BHMT) is a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. BHMT displays differential expression in a model of liver cirrhosis.
ncbi gi num :
157266337
ncbi acc num :
NP_001704.2
ncbi gb acc num :
NM_001713.2
uniprot acc num :
Q93088
ncbi mol weight :
44,998 Da
ncbi pathways :
Cysteine And Methionine Metabolism Pathway (104488); Cysteine And Methionine Metabolism Pathway (103421); Glycine, Serine And Threonine Metabolism Pathway (82949); Glycine, Serine And Threonine Metabolism Pathway (313); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); One Carbon Metabolism Pathway (198756); Sulfur Amino Acid Metabolism Pathway (530753); Trans-sulfuration And One Carbon Metabolism Pathway (920958)
ncbi summary :
This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq, Jul 2008]
uniprot summary :
BHMT: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. Protein type: EC 2.1.1.5; Amino Acid Metabolism - cysteine and methionine; Methyltransferase; Amino Acid Metabolism - glycine, serine and threonine. Chromosomal Location of Human Ortholog: 5q14.1. Cellular Component: protein complex; cytoplasm; cytosol. Molecular Function: betaine-homocysteine S-methyltransferase activity; homocysteine S-methyltransferase activity; zinc ion binding; protein complex binding. Biological Process: S-methylmethionine cycle; protein amino acid methylation; betaine catabolic process; sulfur amino acid metabolic process; S-adenosylmethionine metabolic process; response to organic nitrogen; betaine metabolic process; regulation of homocysteine metabolic process
size1 :
0.01 mg
price1 :
140 USD
size2 :
0.05 mg
price2 :
205
size3 :
1 mg
price3 :
1790
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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