product summary
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company name :
MyBioSource
product type :
protein
product name :
L-Asparaginase
catalog :
MBS142428
quantity :
500 IU
price :
140 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS142428
products type :
Native Protein
products full name :
L-Asparaginase
products short name :
L-Asparaginase
products name syn :
L-Asparaginase; L-Asparaginase; L-Asparaginase
other names :
Isoaspartyl peptidase; Isoaspartyl peptidase; Isoaspartyl peptidase; Beta-aspartyl-peptidase; EcAIII; Isoaspartyl dipeptidaseCleaved into the following 2 chains:Isoaspartyl peptidase subunit alpha; Isoaspartyl peptidase subunit beta
other gene names :
iaaA; iaaA; ECK0818; JW0812; spt; ybiK; spt; ybiK
uniprot entry name :
IAAA_ECOLI
host :
E Coli
sequence length :
321
purity :
Greater than 96.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
The enzyme was lyophilized with no additives. Sterile Filtered White lyophilized (freeze-dried) powder.
concentration :
1mg/ml
storage stability :
Store at -20 degree C, 2 weeks at 4 degree C.
other info1 :
Unit Defenition: One unit of enzyme catalyzes hadrylazation of 10 nanomoles of dUTP to dUMP in one hour at 85 Centigrade. Specific Activity: 225 IU/mg.
other info2 :
Solubility: It is recommended to reconstitute the lyophilized L-Asparaginase in 18MOmega-cm H2O at 1mg/ml. Activity: One IU of L- Asparaginase is defined as that amount of enzyme required to generate 1 umol of ammonia per minute at pH 7.3 and 37 degree C.
products categories :
ENZYMES; Enzymes; Natural Enzymes
products description :
Description: L-Asparaginase was purified from E Coli ASI.357. Introduction: L-Asparaginase is an enzyme that depletes L-Asparagine "an important nutrient for cancer cells" resulting in cancer/tumor cell starvation. L-asparaginase is an anti-tumor agent derived from E.coli.,which can inhibit the growth of malignant cells. It is used mainly for the induction of remission in acute lymphoblastic leukaemia. Because of the lymph node origin of malignant B cells in Multiple Myeloma, L-Asparagine is an essential amino acid for their cell metabolism, and, consequently, L-Asparaginase may be of value in managing the disease.The rationale behind asparaginase is that it takes advantage of the fact that ALL cellsare unable to synthesize the non-essential amino acidasparaginewhereas normal cells are able to make their own asparagine. These leukemic cells depend on circulating asparagine. Asparaginase however catalyzes the conversion of L-asparagine to aspartic acidand ammonia. This deprives the leukemic cell of circulating asparagine.
ncbi gi num :
16128796
ncbi acc num :
NP_415349.1
ncbi gb acc num :
NC_000913.3
uniprot acc num :
P37595
ncbi mol weight :
33,394 Da
ncbi pathways :
Asparagine Degradation I Pathway (547602); Asparagine Degradation I Pathway (139138); Superpathway Of Aspartate And Asparagine Biosynthesis; Interconversion Of Aspartate And Asparagine (1); Superpathway Of Aspartate And Asparagine Biosynthesis; Interconversion Of Aspartate And Asparagine (138134)
ncbi summary :
IaaA is cleaved before Thr179 to expose N-terminal nucleophile and to produce two subunits. [More information is available at EcoGene: EG12407]. Asparaginase III is first synthesized as a proenzyme which is autocatalytically cleaved post-translationally into two smaller polypeptides. [More information is available at EcoCyc: EG12407].
size1 :
500 IU
price1 :
140 USD
size2 :
2500 IU
price2 :
205
size3 :
10000 IU
price3 :
455
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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