Recombinant Human Platelet Derived Growth Factor-BB | MyBioSource MBS142377 product information

product summary

request information :

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Platelet Derived Growth Factor-BB

catalog :

MBS142377

quantity :

0.01 mg

price :

205 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142377

products type :

Recombinant Protein

products full name :

Recombinant Human Platelet Derived Growth Factor-BB

products short name :

Platelet Derived Growth Factor-BB

products name syn :

PDGF BB Human; Platelet-Derived Growth Factor BB Human Recombinant; Glioma-derived growth factor; GDGF; Osteosarcoma-derived Growth Factor; ODGF; SIS; SSV; PDGF2; c-sis; FLJ12858; PDGF-BB; PDGF B-chain; Platelet-derived growth factor beta polypeptide; Becaplermin

other names :

platelet-derived growth factor subunit B isoform 1 preproprotein; Platelet-derived growth factor subunit B; platelet-derived growth factor subunit B; PDGF subunit B; PDGF, B chain; becaplermin; platelet-derived growth factor 2; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor, beta polypeptide (oncogene SIS); proto-oncogene c-Sis; platelet-derived growth factor beta polypeptide; PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Proto-oncogene c-Sis; INN: Becaplermin

products gene name :

PDGF BB

other gene names :

PDGFB; PDGFB; SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2; PDGF2; SIS; PDGF subunit B

uniprot entry name :

PDGFB_HUMAN

host :

E Coli

sequence length :

241

sequence :

SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT.

purity :

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH7.4. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized Platelet-derived Growth Factor BB although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution PDGF BB should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized Platelet-derived Growth Factor-BB in sterile 18M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 1.0-3.0 ng/ml.

products categories :

CYTOKINES AND GROWTH FACTORS; Growth Factors; PDGF

products description :

Description: Platelet-Derived Growth Factor BB Human Recombinant is a homodimeric, non-glycosylated, polypeptide chain containing 2x109 amino acids (218 amino acids in total) and having a molecular mass of 24.3 kDa. PDGF-BB is purified by proprietary chromatographic techniques. Introduction: PDGF-BB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.

ncbi gi num :

4505681

ncbi acc num :

NP_002599.1

ncbi gb acc num :

NM_002608.2

uniprot acc num :

P01127

ncbi mol weight :

25,502 Da

ncbi pathways :

Adaptive Immune System Pathway 366160!!Angiogenesis Pathway 198772!!Choline Metabolism In Cancer Pathway 1059539!!Choline Metabolism In Cancer Pathway 1084232!!Constitutive PI3K/AKT Signaling In Cancer Pathway 685535!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!DAP12 Interactions Pathway 685549!!DAP12 Signaling Pathway 685550!!Disease Pathway 530764

ncbi summary :

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2013]

size :

0.01 mg

price :

205 USD

more info or order :

MyBioSource product webpage