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protein

Recombinant Human Desert HedgeHog

MBS142343

1 mg

2760 USD

MBS142343

Recombinant Protein

Recombinant Human Desert HedgeHog

Desert HedgeHog

DHH Human; Desert Hedgehog Human Recombinant; HHG-3; Desert Hedgehog homolog; MGC35145; Desert hedgehog protein; DHH

desert hedgehog protein preproprotein; Desert hedgehog protein; desert hedgehog protein; desert hedgehog homolog; mutant desert hedgehog; desert hedgehog; HHG-3Cleaved into the following 2 chains:Desert hedgehog protein N-product; Desert hedgehog protein C-product

DHH

DHH; DHH; GDXYM; HHG-3; SRXY7; DHH

DHH_HUMAN

E Coli

396

MGSSHHHHHH SSGLVPRGSH MCGPGRGPVG RRRYARKQLV PLLYKQFVPG VPERTLGASG PAEGRVARGS ERFRDLVPNY NPDIIFKDEE NSGADRLMTE RCKERVNALA IAVMNMWPGV RLRVTEGWDE DGHHAQDSLH YEGRALDITT SDRDRNKYGL LARLAVEAGF DWVYYESRNH VHVSVKADNS LAVRAGG.

Greater than 95.0% as determined by SDS-PAGE.

DHH solution containing 20mM MES pH-5.5, 0.5mM DTT and 20% glycerol. Sterile filtered colorless solution.

1mg/ml

DHH Human Recombinant although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.

CYTOKINES AND GROWTH FACTORS; Cytokines; Hedgehog Protein

Description: DHH Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 197 amino acids (23-198) and having a molecular mass of 22 kDa. DHH is fused to His-tag (20 a.a.) at N-terminus and is purified by proprietary chromatographic techniques. Introduction: DHH is part of the Hedgehog family which encodes signaling molecules that are involved in regulating morphogenesis. DHH protein is a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. Additionally, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in DHH protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. DHH plays a role both male gonadal differentiation and perineurial development.DHH plays a role in intercellular signaling which is essential for a variety of patterning events during development. DHH functions as a spermatocyte survival factor in the testes & is essential for testes development.

19482158

NP_066382.1

NM_021044.2

O43323

43,577 Da

Activation Of SMO Pathway 1127544!!Class B/2 (Secretin Family Receptors) Pathway 106378!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664!!Disease Pathway 530764!!GPCR Ligand Binding Pathway 161020!!Hedgehog 'on' State Pathway 1127542!!Hedgehog Signaling Pathway 198835!!Hedgehog Ligand Biogenesis Pathway 1127536!!Hedgehog Signaling Pathway 1084754!!Hedgehog Signaling Pathway 1108217

This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq, May 2010]

1 mg

2760 USD