protein

Recombinant Rat Interleukin-10

MBS142341

0.01 mg

205 USD

Recombinant Protein

Recombinant Rat Interleukin-10

Interleukin-10

IL 10 Rat; Interleukin-10 Rat Recombinant; B-TCGF; CSIF; TGIF; IL-10; IL10A; MGC126450; MGC126451; Cytokine synthesis inhibitory factor

interleukin-10; Interleukin-10; interleukin-10; CSIF; IL-10; cytokine synthesis inhibitory factor; interleukin 10; Cytokine synthesis inhibitory factor; CSIF

rIL 10

Il10; Il10; IL10X; Il-10; IL-10; CSIF

IL10_RAT

E Coli

178

The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ser-Lys-Gly-His.

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The protein was lyophilized containing 25mM sodium phosphate buffer pH-7.25 and 100mM NaCl. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized IL-10 Rat although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Interleukin10 Rat recombinant should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized IL-10 Rat Recombinant in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50 as determined by the dose dependent inhibition of MC/9 proliferation is less than 10ng/ml concentration corresponding to a Specific Activity of 100,000IU/mg.

CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin

Description: IL-10 Recombinant Rat produced in E Coli is a single, glycosylated polypeptide chain containing 160 amino acids and having a molecular mass of 18.7 kDa. The Interleukin-10 Mouse is purified by proprietary chromatographic techniques. Introduction: IL10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

148747382

NP_036986.2

NM_012854.2

P29456

20,426 Da

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factor involved in the inhibition of cytokine synthesis [RGD, Feb 2006]

0.01 mg

205 USD