protein

Recombinant Human Insulin Like Growth Factor Binding Protein-5

MBS142340

1 mg

3775 USD

Recombinant Protein

Recombinant Human Insulin Like Growth Factor Binding Protein-5

Insulin Like Growth Factor Binding Protein-5

IGFBP 5 Human; Insulin-Like Growth Factor Binding Protein-5 Human Recombinant; IGFBP-5; IBP-5; IGF-binding protein 5

insulin-like growth factor-binding protein 5; Insulin-like growth factor-binding protein 5; insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5; insulin-like growth factor binding protein 5

IGFBP5

IGFBP5; IGFBP5; IBP5; IBP5; IBP-5; IGF-binding protein 5; IGFBP-5

IBP5_HUMAN

E Coli

272

LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAENTAHPRIISA PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK LPGMEYVDGD FQCHTFDSSN VE

Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

IBP-5 was lyophilized from a concentrated (1mg/ml) solution containing 10mM sodium Citrate pH-3. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized IBP5 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IGFBP 5 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized Insulin-Like Growth Factor Binding Protein-5 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50, calculated by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 for this effect is 2500 IU/mg in the presence of 15 ng/ml of rHuIGF-II.

CYTOKINES AND GROWTH FACTORS; Growth Factors; IGFBP

Description: IGFBP5 Human Recombinant produced in E Coli is a single, non-glycosylated, homodimeric polypeptide chain containing 252 amino acids and having a molecular mass of 28.6 kDa. IGFBP5 is purified by proprietary chromatographic techniques. Introduction: IGFBP5 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

10834982

NP_000590.1

NM_000599.3

P24593

30,570 Da

Metabolism Of Proteins Pathway 106230!!Myometrial Relaxation And Contraction Pathways 198759!!Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway 105908!!Senescence And Autophagy Pathway 198780

1 mg

3775 USD