Recombinant Human 4-1BB Receptor | MyBioSource MBS142339 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human 4-1BB Receptor

catalog :

MBS142339

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142339

products type :

Recombinant Protein

products full name :

Recombinant Human 4-1BB Receptor

products short name :

4-1BB Receptor

products name syn :

4 1BBR Human; 4-1BB Receptor Human Recombinant; Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor T-cell; antigen 4-1BB homolog; T-cell antigen ILA; CD137 antigen; CDw137; ILA; 4-1BB; MGC2172; 4-1BBR; TNFRSF9; 4 1BBR

other names :

tumor necrosis factor receptor superfamily member 9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; CD137 antigen; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; tumor necrosis factor receptor superfamily, member 9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CD_antigen: CD137

products gene name :

4 1BBR

other gene names :

TNFRSF9; TNFRSF9; ILA; 4-1BB; CD137; CDw137; CD137; ILA

uniprot entry name :

TNR9_HUMAN

host :

E Coli

sequence length :

255

sequence :

The sequence of the first five N-terminal amino acids was determined and was found to be Met-Glu-Arg-Thr-Arg.

purity :

Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

Lyophilized from a concentrated (1mg/ml) solution in water containing no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized 4-1BB Receptor although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution 4-1BBR should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized 4-1BB Receptor in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The activity was determined by the inhibition of 4-1BB ligand mediated stimulation of IL-8 production by human PBMC. Results: 90% inhibition using 1 ug for both 4-1BB ligand and 4-1BB receptor.

products categories :

CYTOKINES AND GROWTH FACTORS; Cytokines

products description :

Description: 4-1BB Soluble Receptor Recombinant Human also called Tumor necrosis factor receptor superfamily member 9 produced in E Coli is a single, non-glycosylated polypeptide chain containing 167 amino acids, having a molecular mass of 17718 Dalton and containing the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor. The 4-1BB Receptor is purified by proprietary chromatographic techniques. Introduction: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

ncbi gi num :

5730095

ncbi acc num :

NP_001552.2

ncbi gb acc num :

NM_001561.5

uniprot acc num :

Q07011

ncbi mol weight :

27,899 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); TCR Signaling Pathway (198862)

ncbi summary :

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]

uniprot summary :

TNFRSF9: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1p36. Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane. Molecular Function: cytokine binding; receptor activity. Biological Process: negative regulation of cell proliferation; apoptosis

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage