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protein

Recombinant Mouse RELM-alpha His Tag

MBS142329

1 mg

3845 USD

MBS142329

Recombinant Protein

Recombinant Mouse RELM-alpha His Tag

RELM-alpha

RELM a Mouse, His; RELM-Alpha Mouse Recombinant, His Tag; Resistin-like alpha; RELMalpha; Cysteine-rich secreted protein FIZZ1; Parasite-induced macrophage novel gene 1 protein; Cysteine-rich secreted protein A12-gamma; RELM-a; mRELM a His

resistin-like alpha; Resistin-like alpha; resistin-like alpha; cysteine-rich secreted protein A12-gamma; cysteine-rich secreted protein FIZZ1; found in inflammatory zone 1; hypoxia-induced mitogenic factor; parasite-induced macrophage novel gene 1 protein; resistin like alpha; Cysteine-rich secreted protein A12-gamma; Cysteine-rich secreted protein FIZZ1; Hypoxia-induced mitogenic factor; Parasite-induced macrophage novel gene 1 protein; RELMalpha

mRELM a

Retnla; Retnla; HIMF; Xcp2; Fizz1; RELMa; Fizz-1; RELMalpha; RELM-alpha; 1810019L16Rik; Fizz1; Himf; Pmng1

RETNA_MOUSE

E Coli

138

Greater than 95% as determined by SDS-PAGE.

Filtered and lyophilized from 0.5 mg/ml in 5mM Tris pH 7.5, 25mM NaCl. Filtered White lyophilized (freeze-dried) powder.

Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

Solubility: Add 0.2 ml of deionized H2O and let the lyophilized pellet dissolve completely.

CYTOKINES AND GROWTH FACTORS; Cytokines; Resistin

Description: RELM-alpha Mouse Recombinant is manufactured with a signal sequence of phage fd (20aa) and C-terminal fusion of flagTag (10aa). The RELM-alpha Flag-Tagged Fusion Protein is a 13.3 kDa protein containing 91 amino acid residues with 30 additional amino acid residues - signal sequence of phage fd, flagTag (underlined). Introduction: Bronchoalveolar lavage fluid from mice with experimentally induced allergic pulmonary inflammation contains a novel 9.4 kDa cysteine-rich secreted protein, RELM-alpha (FIZZ1, found in inflammatory zone). RELM-alpha is a secreted protein that has a restricted tissue distribution with highest levels in adipose tissue stroma. Murine RELM-alpha (FIZZ1) is the founding member of a new gene family including two other murine genes expressed, respectively, in intestinal crypt epithelium (RELM-beta) and white adipose tissue (Resistin), and two related human genes.RELMalpha inhibits the differentiation of 3T3-L1 preadipocytes into adipocytes but has no effect on proliferation of 3T3-L1 preadipocytes. RELMalpha is able to form heterooligomers with resistin but not RELMbeta. Since RELMalpha is expressed by adipose tissue and it is a secreted factor, our findings suggest that RELMalpha may be involved in the control of the adipogenesis as well as in the process of muscle differentiation.In the lung, RELM-alpha is induced by hypoxia and was renamed as hypoxia-induced mitogenic factor (HIMF). HIMF strongly activated Akt phosphorylation. The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 (10 micromol/L) inhibited HIMF-activated Akt phosphorylation. It also inhibited HIMFstimulated RPSM proliferation. Thus, the PI3K/Akt pathway, at least in part, mediates the proliferative effect of HIMF. Further studies showed that HIMF had angiogenic and vasoconstrictive properties. HIMF increased pulmonary arterial pressure and vascular resistance. Further studies suggest that HIMF regulates apoptosis and may participate in lung alveolarization and maturation.

103472022

NP_065255.2

NM_020509.3

Q9EP95

11,936 Da

1 mg

3845 USD