Recombinant Human Myostatin Propeptide | MyBioSource MBS142324 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Myostatin Propeptide

catalog :

MBS142324

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142324

products type :

Recombinant Protein

products full name :

Recombinant Human Myostatin Propeptide

products short name :

Myostatin

products name syn :

Myostatin Propeptide Human; Myostatin Propeptide Human Recombinant; GDF-8; MSTN; Growth Differentiation Factor 8; MSTN Muscle Hypertrophy; Myostatin Propetide

other names :

growth/differentiation factor 8; Growth/differentiation factor 8; growth/differentiation factor 8; GDF-8; growth differentiation factor 8; myostatin; Myostatin

other gene names :

MSTN; MSTN; GDF8; MSLHP; GDF8; GDF-8

uniprot entry name :

GDF8_HUMAN

host :

E Coli

sequence length :

375

sequence :

MNENSEQKE NVEKEGLCNA CTWRQNTKSS RIEAIKIQIL SKLRLETAPN ISKDVIRQLL PKAPPLRELI DQYDVQRDDS SDGSLEDDDY HATTETIITM PTESDFLMQV DGKPKCCFFK FSSKIQYNKV VKAQLWIYLR PVETPTTVFV QILRLIKPMK DGTRYTGIRS LKLDMNPGTG IWQSIDVKTV LQNWLKQPES NLGIEIKALD ENGHDLAVTF PGPGEDGLNP FLEVKVTDTP KRSRR.

purity :

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

Lyophilized from 10mM Acetic Acid. Sterile Filtered white lyophilized (freeze-dried) powder.

storage stability :

Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized Myostatin Propeptide in sterile 50mM Acetic Acid at 0.1 mg/ml, which can then be further diluted to other aqueous solutions.

products categories :

CYTOKINES AND GROWTH FACTORS; Growth Factors; Myostatin

products description :

Description: Recombinant Human Myostatin Propeptide is a 27.8 kDa protein containing 244 amino acid residues of the human Myostatin Propeptide. Introduction: Myostatin (GDF-8), a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide. The myostatin propeptide is negative regulator of myostatin in vivo.

ncbi gi num :

4885259

ncbi acc num :

NP_005250.1

ncbi gb acc num :

NM_005259.2

uniprot acc num :

O14793

ncbi mol weight :

42,750 Da

ncbi pathways :

Hypertrophy Model Pathway (198828)

ncbi summary :

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. [provided by RefSeq, Jul 2008]

uniprot summary :

MSTN: Acts specifically as a negative regulator of skeletal muscle growth. Defects in MSTN are the cause of muscle hypertrophy (MSLHP). MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 2q32.2. Cellular Component: extracellular space; cytoplasm. Molecular Function: heparin binding; identical protein binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding; receptor binding. Biological Process: response to gravity; muscle development; response to muscle activity; positive regulation of transcription, DNA-dependent; skeletal muscle regeneration; response to testosterone stimulus; ovulation cycle process; regulation of apoptosis; skeletal muscle atrophy; response to ethanol; negative regulation of muscle hypertrophy; response to heat; response to estrogen stimulus; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway; negative regulation of skeletal muscle growth; response to electrical stimulus; cell development. Disease: Muscle Hypertrophy

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.025 mg

price2 :

205

size3 :

1 mg

price3 :

4550

more info or order :

MyBioSource product webpage