Recombinant Human Myostatin, His-Tag | MyBioSource MBS142321 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Myostatin, His-Tag

catalog :

MBS142321

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142321

products type :

Recombinant Protein

products full name :

Recombinant Human Myostatin, His-Tag

products short name :

Myostatin

products name syn :

Myostatin Human, His; Myostatin Human Recombinant, His Tag; GDF-8; MSTN; Growth/Differentiation Factor 8; MSTN Muscle Hypertrophy; Myostatin His

other names :

growth/differentiation factor 8; Growth/differentiation factor 8; growth/differentiation factor 8; GDF-8; growth differentiation factor 8; myostatin; Myostatin

other gene names :

MSTN; MSTN; GDF8; MSLHP; GDF8; GDF-8

uniprot entry name :

GDF8_HUMAN

host :

E Coli

sequence length :

375

sequence :

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDPSSRSAVR SRRDFGLDCD EHSTESRCCR YPLTVDFEAFGQSQIIAPKR YKANYCSGEC EFVFLQKYPH THLVHQANPR GSAFPCCTPT KMSPINMLYF NGKEQIIYGKIPAMVVDRCG CS

purity :

Greater than 95% as determined by SDS-PAGE.

form :

Filtered (0.4 um) and lyophilized from 0.5 mg/ml in 0.05M acetate buffer, pH 4.5. Filtered white lyophilized (freeze-dried) powder.

storage stability :

Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

other info2 :

Solubility: Add 0.1M Acetate buffer pH-4 to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10ug/ml. In higher concentrations the solubility of this antigen is limited.

products categories :

CYTOKINES AND GROWTH FACTORS; Growth Factors; Myostatin

products description :

Description: Total 152AA. M.W. 16.7kDa (calculated). N-terminal His-tag and spacer (43AA highlighted). The AA sequence of the human myostatin part of the fusion protein is corresponding to the UniProtKB/Swiss-Prot entry O14793. Introduction: Myostatin (GDF-8) is expressed uniquely in human skeletal muscle as a 12 kDa mature glycoprotein consisting of 113 amino acid residues and secreted into plasma. Myostatin is a member of the transforming growth factor ? superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass. Studies have shown that myostatin could play an important role in cardiac development and physiology.

ncbi gi num :

4885259

ncbi acc num :

NP_005250.1

ncbi gb acc num :

NM_005259.2

uniprot acc num :

O14793

ncbi pathways :

Hypertrophy Model Pathway (198828)

ncbi summary :

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. [provided by RefSeq, Jul 2008]

uniprot summary :

MSTN: Acts specifically as a negative regulator of skeletal muscle growth. Defects in MSTN are the cause of muscle hypertrophy (MSLHP). MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 2q32.2. Cellular Component: extracellular space; cytoplasm. Molecular Function: heparin binding; identical protein binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding; receptor binding. Biological Process: response to gravity; response to muscle activity; muscle development; positive regulation of transcription, DNA-dependent; skeletal muscle regeneration; response to testosterone stimulus; regulation of apoptosis; ovulation cycle process; negative regulation of muscle hypertrophy; skeletal muscle atrophy; response to ethanol; response to heat; response to estrogen stimulus; transforming growth factor beta receptor signaling pathway; regulation of MAPKKK cascade; response to electrical stimulus; negative regulation of skeletal muscle growth; cell development. Disease: Muscle Hypertrophy

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

4005

more info or order :

MyBioSource product webpage