Recombinant Human Cardiotrophin-1 | MyBioSource MBS142312 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Cardiotrophin-1

catalog :

MBS142312

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142312

products type :

Recombinant Protein

products full name :

Recombinant Human Cardiotrophin-1

products short name :

Cardiotrophin-1

products name syn :

CT 1 Human; Cardiotrophin-1 Human Recombinant; CTF1; CT1; CT-1; Cardiophin 1

other names :

cardiotrophin-1 isoform 2; Cardiotrophin-1; cardiotrophin-1; cardiophin 1; cardiotrophin 1

products gene name :

CT 1

other gene names :

CTF1; CTF1; CT1; CT-1; CT-1

uniprot entry name :

CTF1_HUMAN

host :

E Coli

sequence length :

200

purity :

Purity of CTF1 Human Recombinant is greater than 90% as determined by SDS-PAGE.

form :

CT-1 was filtered (0.4 um) and lyophilized from 0.5 mg/ml in 0.05M Acetate buffer pH-4.

storage stability :

Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

other info2 :

Solubility: It is recommended to add 0.1M Acetate buffer pH-4 to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10ug/ml. In higher concentrations the solubility of this antigen is limited. Protein is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

products categories :

CYTOKINES AND GROWTH FACTORS; Cytokines; Cardiotrophin

products description :

Description: The Cardiotrophin His-Tagged Fusion Protein Human, produced in E Coli, is 22.5 kDa protein containing 200 amino acid residues of the human Cardiotrophin and 12 additional amino acid residues His Tag (underlined). Introduction: Cardiotrophin 1 (CT-1) is a 201 amino acid member of the interleukin-6 superfamily. It was identified by its ability to induce hypertrophic response in cardiac myocytes. CT-1 mRNA levels were found both in cardiac myocytes and in cardiac nonmyocytes. CT 1 was also detected in abundance in normal adult human lung and was expressed in both fetal and adult airway smooth muscle cells. CT 1 activates gp130 dependent signaling and stimulates the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway to transduce hypertrophic and cytoprotective signals in cardiac myocytes.CT 1 has also a neurotrophic function. CTF1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice during a period between embryonic day 14 and the first postnatal week. Moreover, CT-1 is a hepatocyte survival factor that efficiently reduces hepatocellular damage in animal models of acute liver injury. Cardiotrophin 1 expression is augmented after hypoxic stimulation and it can protect cardiac cells when added either prior to simulated ischaemia or at the time of reoxygenation following simulated ischaemia. Cardiotrophin 1 can induce expression of the protective heat shock proteins (hsps) in cardiac cells.Cardiotrophin-1 increased ventricular expression of ANP, brain natriuretic peptide (BNP) and angiotensinogen mRNA.Cardiophin 1 levels were significantly elevated in patients with heart failure, patients with dilatative cardiomyopathy, moderate/severe mitral regurgitation, stable and unstable angina and after acute myocardial infarction.

ncbi gi num :

216548056

ncbi acc num :

NP_001136016.1

ncbi gb acc num :

NM_001142544.1

uniprot acc num :

Q16619

ncbi mol weight :

21,098 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); MicroRNAs In Cardiomyocyte Hypertrophy Pathway (198784); Physiological And Pathological Hypertrophy Of The Heart Pathway (920978)

ncbi summary :

The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

uniprot summary :

CTF1: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cytokine. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: extracellular space; extracellular region. Molecular Function: leukemia inhibitory factor receptor binding; cytokine activity. Biological Process: cell proliferation; nervous system development; muscle development; cell-cell signaling; leukemia inhibitory factor signaling pathway; positive regulation of cell proliferation; neuron development

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

4630

more info or order :

MyBioSource product webpage