Recombinant Human Macrophage Migration Inhibitor Factor, His Tag N-Terminus | MyBioSource MBS142307 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Macrophage Migration Inhibitor Factor, His Tag N-Terminus

catalog :

MBS142307

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142307

products type :

Recombinant Protein

products full name :

Recombinant Human Macrophage Migration Inhibitor Factor, His Tag N-Terminus

products short name :

Macrophage Migration Inhibitor Factor N-Terminus

products name syn :

MIF Human His N; Macrophage Migration Inhibitory Factor Human, Recombinant His Tag N-Terminus; Phenylpyruvate tautomerase; Glycosylation-inhibiting factor; GIF; MMIF; MIF; MIF His N

other names :

macrophage migration inhibitory factor; Macrophage migration inhibitory factor; macrophage migration inhibitory factor; L-dopachrome isomerase; L-dopachrome tautomerase; phenylpyruvate tautomerase; macrophage migration inhibitory factor (glycosylation-inhibiting factor); Glycosylation-inhibiting factor; GIF; L-dopachrome isomerase; L-dopachrome tautomerase (EC:5.3.3.12); Phenylpyruvate tautomerase

products gene name :

MIF

other gene names :

MIF; MIF; GIF; GLIF; MMIF; GLIF; MMIF; MIF; GIF

uniprot entry name :

MIF_HUMAN

host :

E Coli

sequence length :

115

purity :

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

1mg/ml solution containing PBS pH-7.4. Sterile filtered colorless solution.

storage stability :

Liquid MIF although stable 4 degree C for 1 week, should be stored below -18 degree C. Please prevent freeze-thaw cycles.

products categories :

CYTOKINES AND GROWTH FACTORS; Growth Factors; Macrophage Migration Inhibitory Factor

products description :

Description: MIF human Recombinant, fused to His-tag at N-terminus, was cloned into an E Coli expression vector and was purified to apparent homogeneity by using conventional column chromatography techniques. Macrophage Inducing Factor Human Recombinant is a single, non-glycosylated, polypeptide chain having amino acids from 1-114 and having a molecular mass of 16.6 kDa. Introduction: The cytokine Macrophage migration inhibitory factor (MIF) has been identified to be secreted by the pituitary gland and the monocyte/macrophage and to play an important role in endotoxic shock. MIF has the unique property of being released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secretion of MIF is tightly regulated and decreases at high, anti-inflammatory steroid concentration.

ncbi gi num :

4505185

ncbi acc num :

NP_002406.1

ncbi gb acc num :

NM_002415.1

uniprot acc num :

P14174

ncbi mol weight :

12,476 Da

ncbi pathways :

Adipogenesis Pathway (198832); Phenylalanine Metabolism Pathway (82960); Phenylalanine Metabolism Pathway (327); Spinal Cord Injury Pathway (739007); Tyrosine Metabolism Pathway (82959); Tyrosine Metabolism Pathway (325)

ncbi summary :

This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]

uniprot summary :

MIF: a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. Also acts as a phenylpyruvate tautomerase. Protein type: EC 5.3.2.1; Cytokine; Isomerase; Apoptosis; EC 5.3.3.12; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Cell development/differentiation. Chromosomal Location of Human Ortholog: 22q11.23. Cellular Component: nucleoplasm; extracellular space; cell surface; cytoplasm; extracellular region; vesicle. Molecular Function: phenylpyruvate tautomerase activity; protein binding; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine activity; dopachrome isomerase activity; chemoattractant activity; receptor binding. Biological Process: DNA damage response, signal transduction by p53 class mediator; regulation of macrophage activation; carboxylic acid metabolic process; positive regulation of lipopolysaccharide-mediated signaling pathway; cell aging; negative regulation of cellular protein metabolic process; prostaglandin biosynthetic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of MAP kinase activity; negative regulation of DNA damage response, signal transduction by p53 class mediator; cell proliferation; positive regulation of fibroblast proliferation; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of myeloid cell apoptosis; cell surface receptor linked signal transduction; negative regulation of mature B cell apoptosis; positive chemotaxis; positive regulation of B cell proliferation; innate immune response; inflammatory response; positive regulation of phosphorylation; negative regulation of apoptosis; positive regulation of cytokine secretion. Disease: Rheumatoid Arthritis, Systemic Juvenile

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.025 mg

price2 :

205

size3 :

1 mg

price3 :

1790

more info or order :

MyBioSource product webpage