Recombinant Human BAFF (BLyS) Receptor | MyBioSource MBS142305 product information

product summary

request information :

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human BAFF (BLyS) Receptor

catalog :

MBS142305

quantity :

0.01 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142305

products type :

Recombinant Protein

products full name :

Recombinant Human BAFF (BLyS) Receptor

products short name :

BAFF

products name syn :

BAFF R Human; B-cell Activating Factor Receptor Human Recombinant; TNFRSF13C; CD268; BAFF-R; MGC138235; B cell-activating factor receptor; BAFF R

other names :

tumor necrosis factor receptor superfamily member 13C; Tumor necrosis factor receptor superfamily member 13C; tumor necrosis factor receptor superfamily member 13C; B cell-activating factor receptor; B-cell-activating factor receptor; BAFF receptor; BLyS receptor 3; tumor necrosis factor receptor superfamily, member 13C; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD_antigen: CD268

products gene name :

BAFF

other gene names :

TNFRSF13C; TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin; BAFFR; BR3; BAFF-R

uniprot entry name :

TR13C_HUMAN

host :

E Coli

sequence length :

184

sequence :

MRRGPRSLRGRDAPAPTPCVPAECFDLLVRHCVACGLLR
TPRPKPAGASSPAPRTALQPQESVGAGAGEAALPLPG.

purity :

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

Lyophilized from a 0.2um filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 8.0, 500mM NaCl. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized BAFF-R although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution B Lymphocyte Stimulator Receptor should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized B Lymphocyte Stimulator Receptor Recombinant in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED50 for this effect is 1.0-5.0 ug/ml in the presence of 1.0 ug/ml of human soluble BAFF.

products categories :

CYTOKINES AND GROWTH FACTORS; Cytokines; B-Cell Activating Factor

products description :

Description: B Lymphocyte Stimulator Receptor Human Recombinant extracellular produced in E Coli is a single, non-glycosylated polypeptide chain containing 76 amino acids and having a molecular mass of 7.7 kDa.The BAFF-R is purified by proprietary chromatographic techniques. Introduction: B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.

ncbi gi num :

16445027

ncbi acc num :

NP_443177.1

ncbi gb acc num :

NM_052945.3

uniprot acc num :

Q96RJ3

ncbi mol weight :

18,935 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!HTLV-I Infection Pathway 373901!!HTLV-I Infection Pathway 373889!!Intestinal Immune Network For IgA Production Pathway 128760!!Intestinal Immune Network For IgA Production Pathway 128670!!NF-kappa B Signaling Pathway 634527!!Primary Immunodeficiency Pathway 83125!!Primary Immunodeficiency Pathway 537

ncbi summary :

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

size :

0.01 mg

price :

140 USD

more info or order :

MyBioSource product webpage