Recombinant Human Placenta Growth Factor-1 | MyBioSource MBS142295 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Placenta Growth Factor-1

catalog :

MBS142295

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142295

products type :

Recombinant Protein

products full name :

Recombinant Human Placenta Growth Factor-1

products short name :

Placenta Growth Factor-1

products name syn :

PLGF 1 Human; Placenta Growth Factor-1 Human Recombinant; PIGF; PGF; PLGF-1; PlGF-2

other names :

placenta growth factor isoform 2; Placenta growth factor; placenta growth factor; placental growth factor, vascular endothelial growth factor-related protein; placental growth factor

products gene name :

PLGF 1

other gene names :

PGF; PGF; PGFL; PLGF; PlGF-2; D12S1900; SHGC-10760; PGFL; PLGF; PlGF

uniprot entry name :

PLGF_HUMAN

host :

Insect Cells

sequence length :

149

sequence :

The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Pro-Ala-Val.

purity :

Greater than 90.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

Lyophilized from a concentrated (1mg/ml) solution containing no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized Placenta Growth Factor 1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution PLGF1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized Placenta Growth Factor 1 in sterile 0.1M acetic acid or PBS not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50 as determined by its ability to bind to immobilized rh-sFlt-1 in a functional ELISA. PlGF-1 human Recombinant can bind to immobilized rh-sFlt-1 (100ng/well) with a linear range at 0.5-10ng/ml, corresponding to a Specific Activity of 1x105-2x106units/mg.

products categories :

CYTOKINES AND GROWTH FACTORS; Growth Factors

products description :

Description: Placenta Growth Factor-1 Human Recombinant produced in insect cells is a homodimer, glycosylated polypeptide chain containing 2 x 131 amino acids and having a total molecular mass of approximately 34 kDa. The PLGF-1 is purified by proprietary chromatographic techniques. Introduction: PLGF is a growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. It binds to receptor vegfr-1/flt1.

ncbi gi num :

333033785

ncbi acc num :

NP_001193941.1

ncbi gb acc num :

NM_001207012.1

uniprot acc num :

P49763

ncbi mol weight :

19,338 Da

ncbi pathways :

Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); PI3K-Akt Signaling Pathway (692234); PI3K-Akt Signaling Pathway (692979); Pathways In Cancer (83105); Rap1 Signaling Pathway (868086); Rap1 Signaling Pathway (878042); Ras Signaling Pathway (868085); Signal Transduction Pathway (477114)

ncbi summary :

This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]

uniprot summary :

PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 14q24.3. Cellular Component: extracellular space; membrane; extracellular region. Molecular Function: heparin binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity. Biological Process: response to drug; organ regeneration; positive regulation of angiogenesis; cell-cell signaling; ureteric bud branching; positive regulation of cell division; positive regulation of cell proliferation; response to hypoxia; positive regulation of endothelial cell proliferation; sprouting angiogenesis; female pregnancy; cell differentiation; signal transduction; vascular endothelial growth factor receptor signaling pathway; cellular response to hormone stimulus

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

4140

more info or order :

MyBioSource product webpage