Recombinant Human Fibroblast Growth Factor-9 | MyBioSource MBS142291 product information

product summary

request information :

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Fibroblast Growth Factor-9

catalog :

MBS142291

quantity :

0.02 mg

price :

205 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142291

products type :

Recombinant Protein

products full name :

Recombinant Human Fibroblast Growth Factor-9

products short name :

Fibroblast Growth Factor-9

products name syn :

FGF 9 Human; Fibroblast Growth Factor-9 Human Recombinant; GAF (Glia-activating factor); HBGF-9; MGC119914; MGC119915; FGF-9

other names :

fibroblast growth factor 9; Fibroblast growth factor 9; fibroblast growth factor 9; fibroblast growth factor 9 (glia-activating factor); heparin-binding growth factor 9; fibroblast growth factor 9; Glia-activating factor; GAF; Heparin-binding growth factor 9; HBGF-9

products gene name :

FGF 9

other gene names :

FGF9; FGF9; GAF; FGF-9; SYNS3; HBFG-9; HBGF-9; FGF-9; GAF; HBGF-9

uniprot entry name :

FGF9_HUMAN

host :

E Coli

sequence length :

208

sequence :

APLGEVGNYF GVQDAVPFGN VPVLPVDSPV LLSDHLGQSE AGGLPRGPAVTDLDHLKGIL RRRQLYCRTG FHLEIFPNGT IQGTRKDHSR FGILEFISIAVGLVSIRGVD SGLYLGMNEK GELYGSEKLT QECVFREQFE ENWYNTYSSNLYKHVDTGRR YYVALNKDGT PREGTRTKRH QKFTHFLPRP VDPDKVPELYKDILSQS.

purity :

Greater than 95.0% as determined by RP-HPLC and SDS-PAGE.

form :

The sterile protein powder is lyophilized from 1mg/ml solution containing 1xPBS. Sterile Filtered white lyophilized powder.

storage stability :

Lyophilized Fibroblast Growth Factor 9 Human Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution FGF-9 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized Fibroblast Growth Factor-9 Human Recombinant sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50, calculated by the dose-dependant proliferation of BAF3 cells expressing FGF receptors (measured by 3H-thymidine uptake) is <0.5ng/ml, corresponding to a specific activity of 2,000,000 Units/mg.

products categories :

CYTOKINES AND GROWTH FACTORS; Growth Factors; Fibroblast Growth Factor

products description :

Description: Fibroblast Growth Factor-9 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 207 amino acids and having a molecular mass of 23.4 kDa. The FGF-9 is purified by proprietary chromatographic techniques. Introduction: The human FGF-9 cDNA encodes a 208 amino acid residue protein that contains a single, potential N-linked glycosylation site. The native protein is glycosylated and is efficiently secreted after synthesis, although FGF -9 lacks a typical secretion signal. Rat and mouse FGF-9 show a very high homology to human FGF-9. The transcripts for FGF-9 have been found in brain and in kidney tissue. Fibroblast Growth Factor-9 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF9 was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis Fibroblast Growth Factor 9 may have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.

ncbi gi num :

4503707

ncbi acc num :

NP_002001.1

ncbi gb acc num :

NM_002010.2

uniprot acc num :

P31371

ncbi mol weight :

23,441 Da

ncbi pathways :

Activated Point Mutants Of FGFR2 Pathway 645281!!Adaptive Immune System Pathway 366160!!Constitutive PI3K/AKT Signaling In Cancer Pathway 685535!!DAP12 Interactions Pathway 685549!!DAP12 Signaling Pathway 685550!!Disease Pathway 530764!!Downstream Signal Transduction Pathway 106385!!Downstream Signaling Events Of B Cell Receptor (BCR) Pathway 576250!!Downstream Signaling Of Activated FGFR Pathway 160957!!FGFR Ligand Binding And Activation Pathway 106344

ncbi summary :

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. [provided by RefSeq, Jul 2008]

size :

0.02 mg

price :

205 USD

more info or order :

MyBioSource product webpage