catalog number :
MBS142276
products type :
Recombinant Protein
products full name :
Recombinant Porcine Interleukin-1 beta
products short name :
Interleukin-1 beta
products name syn :
IL 1 beta Porcine; Interleukin-1 beta Porcine Recombinant; Catabolin; Lymphocyte-activating factor (LAF); Endogenous Pyrogen (EP); Leukocyte Endogenous Mediator (LEM); Mononuclear Cell Factor (MCF); IL1F2; IL-1 beta
other names :
interleukin-1 beta; Interleukin-1 beta; interleukin-1 beta; IL-1 beta; prointerleukin-1 beta; N/A
products gene name :
pIL 1 beta
other gene names :
IL1B1; IL1B; IL1B; IL-1 beta
uniprot entry name :
IL1B_PIG
sequence :
ANVQSMECKL QDKDHKSLVL AGPHMLKALH LLTGDLKREV VFCMSFVQGD DSNNKIPVTL GIKGKNLYLS CVMKDNTPTL QLEDIDPKRY PKRDMEKRFV FYKTEIKNRV EFESALYPNW YISTSQAEQK PVFLGNSKGR QDITDFTMEV LSP
purity :
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
The IL 1 beta was lyophilized from a 0.2 um filtered concentrated solution in PBS pH 7.4, containing 3 % trehalose. Sterile Filtered White lyophilized (freeze-dried) powder.
other info2 :
Solubility: It is recommended to reconstitute the lyophilized IL 1 beta in sterile distilled H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 5.0 ng/ml, corresponding to a specific activity of > 2.0 x 105 IU/mg.
products categories :
CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
products description :
Description: Recombinant IL 1 beta Porcine produced in E Coli cells is a non-glycosylated, homodimeric protein containing 153 amino acid chain and having a molecular mass of 17.6kDa. The IL 1 beta is purified by proprietary chromatographic techniques. Introduction: Interleukin-1b is produced by activated macrophages, IL-1B stimulates thymocyte proliferation by inducing il-2 release, b-cell maturation and proliferation, and fibroblast growth factor activity. IL1B proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
ncbi acc num :
NP_999220.1
ncbi gb acc num :
NM_214055.1
ncbi mol weight :
30,404 Da
ncbi pathways :
African Trypanosomiasis Pathway 194379!!African Trypanosomiasis Pathway 194323!!Alzheimer's Disease Pathway 84508!!Alzheimer's Disease Pathway 509!!Amoebiasis Pathway 167313!!Amoebiasis Pathway 167191!!Apoptosis Pathway 84472!!Apoptosis Pathway 470!!Chagas Disease (American Trypanosomiasis) Pathway 147807!!Chagas Disease (American Trypanosomiasis) Pathway 147795