catalog number :
MBS142273
products type :
Recombinant Protein
products full name :
Recombinant Porcine Interleukin-2
products short name :
Interleukin-2
products name syn :
IL 2 Porcine; Interleukin-2 Porcine Recombinant; T-cell growth factor (TCGF); Aldesleukin; Lymphokine; IL-2
other names :
interleukin-2; Interleukin-2; interleukin-2; T-cell growth factor; T-cell growth factor; TCGF
products gene name :
pIL 2
other gene names :
IL2; IL2; IL-2; TCGF; POIL2; IL-2; TCGF
uniprot entry name :
IL2_PIG
sequence :
The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ala-Pro-Thr-Ser.
purity :
Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
The protein (1mg/ml) was lyophilized containing no additives. Sterile Filtered White lyophilized (freeze-dried) powder.
storage stability :
Lyophilized IL2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL-2 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
other info2 :
Solubility: It is recommended to reconstitute the lyophilized Interferon 2 in sterile 20mM AcOH not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50 as determined by the dose-dependant murine CTLL cells proliferation assay with MTS detection is < 0.1ng/ml, corresponding to a Specific Activity of 10,000,000IU/mg.
products categories :
CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
products description :
Description: Interleukin2 Porcine Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 134 amino acids and having a molecular mass of 15217 Dalton. The IL-2 is purified by proprietary chromatographic techniques. Introduction: IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
ncbi acc num :
NP_999026.1
ncbi gb acc num :
NM_213861.1
ncbi mol weight :
17,401 Da
ncbi pathways :
Allograft Rejection Pathway 84530!!Allograft Rejection Pathway 535!!Autoimmune Thyroid Disease Pathway 84528!!Autoimmune Thyroid Disease Pathway 533!!Chagas Disease (American Trypanosomiasis) Pathway 147807!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Cytokine Signaling In Immune System Pathway 1125176!!Cytokine-cytokine Receptor Interaction Pathway 84463!!Cytokine-cytokine Receptor Interaction Pathway 460!!Graft-versus-host Disease Pathway 84531