product summary
request information :
company name :
MyBioSource
product type :
protein
product name :
Recombinant Rat Tumor Necrosis Factor-alpha
catalog :
MBS142269
quantity :
0.02 mg
price :
205 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS142269
products type :
Recombinant Protein
products full name :
Recombinant Rat Tumor Necrosis Factor-alpha
products short name :
Tumor Necrosis Factor-alpha
products name syn :
TNF a Rat; Tumor Necrosis Factor-Alpha Rat Recombinant; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin; DIF; TNFA; TNFSF2
other names :
tumor necrosis factor; Tumor necrosis factor; tumor necrosis factor; cachectin; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a
products gene name :
rTNF a
other gene names :
Tnf; Tnf; Tnfa; RATTNF; TNF-alpha; Tnfa; Tnfsf2; TNF-a; NTF; ICD1; ICD2
uniprot entry name :
TNFA_RAT
host :
E Coli
sequence length :
235
sequence :
MLRSSSQNSS DKPVVHVVAN HQAEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLIY SQVLFKGQGC PDYVLLTHTV SRFATSYQEK VSLLSAIKSP CPKDTPEGAE LKPWYEPMYL GGVSQLEKGD LLSAEVNLPK YLDITESGQV YFGVIAL.
purity :
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
The concentrated protein solution (1mg/ml) was lyophilized from 20mM phosphate buffer and 0.1M NaCl. Sterile Filtered White lyophilized (freeze-dried) powder.
storage stability :
Lyophilized Tumor Necrosis Factor-a although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution TNF-a should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
other info2 :
Solubility: It is recommended to reconstitute the lyophilized Tumor Necrosis Factor-alpha in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin D is < 0.05ng/ml, corresponding to a Specific Activity of 20,000,000 IU/mg.
products categories :
CYTOKINES AND GROWTH FACTORS; Cytokines; Tumor Necrosis Factor
products description :
Description: Tumor Necrosis Factor-a Rat Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 157 amino acids and having a molecular mass of 17339.44 Dalton. The TNF-alpha is purified by standard chromatographic techniques. Introduction: Tumor necrosis factor is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is mainly secreted by macrophages. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis and viral replication, TNF is also involved in lipid metabolism, and coagulation. TNF's primary role is in the regulation of immune cells.Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases- autoimmune diseases, insulin resistance, and cancer.
ncbi gi num :
6981662
ncbi acc num :
NP_036807.1
ncbi gb acc num :
NM_012675.3
uniprot acc num :
P16599
ncbi mol weight :
25,806 Da
ncbi pathways :
Adipocytokine Signaling Pathway 83485!!Adipocytokine Signaling Pathway 505!!Adipogenesis Pathway 198479!!African Trypanosomiasis Pathway 194377!!African Trypanosomiasis Pathway 194323!!Allograft Rejection Pathway 83511!!Allograft Rejection Pathway 535!!Alzheimer's Disease Pathway 83489!!Alzheimer's Disease Pathway 509!!Amoebiasis Pathway 167311
ncbi summary :
acts as a cytokine; binds TNF receptors; plays a role in regulation of cell proliferation, induction of apoptosis, and inflammatory response [RGD, Feb 2006]
size :
0.02 mg
price :
205 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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