product summary
request information :
company name :
MyBioSource
product type :
protein
product name :
Recombinant Rat Interleukin-4
catalog :
MBS142262
quantity :
0.02 mg
price :
205 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS142262
products type :
Recombinant Protein
products full name :
Recombinant Rat Interleukin-4
products short name :
Interleukin-4
products name syn :
IL 4 Rat; Interleukin-4 Rat Recombinant; BCGF; BCDF; B cell stimulating factor; BSF-1; Lymphocyte stimulatory factor 1; IL-4; MGC79402; Binetrakin; Pitrakinra
other names :
interleukin-4; Interleukin-4; interleukin-4; B-cell IGG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; IL-4; lymphocyte stimulatory factor 1; interleukin 4; B-cell IGG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1
products gene name :
rIL 4
other gene names :
Il4; Il4; Il4e12; Il-4; IL-4; BSF-1
uniprot entry name :
IL4_RAT
host :
E Coli
sequence length :
147
sequence :
MHGCNDSPLR EIINTLNQVT EKGTPCTEMF VPDVLTATRN TTENELICRA SRVLRKFYFP RDVPPCLKNK SGVLGELRKL CRGVSGLNSL RSCTVNESTL TTLKDFLESL KSILRGKYLQ SCTSMS.
purity :
Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
Lyophilized from a concentrated (1mg/ml) solution in water containing no additives. Sterile Filtered White lyophilized (freeze-dried) powder.
storage stability :
Lyophilized Interleukin-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL4 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
other info2 :
Solubility: It is recommended to reconstitute the lyophilized Interleukin 4 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Protein Content: Protein quantitation was carried out by two independent methods: 1. UV spectroscopy at 280 nm using the absorbency value of 0.2 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a standard solution of IL-4 as a Reference Standard. Biological Activity: Determined by its ability to suppress LPS-induced TNF-alpha and MIP-2 production in mouse splenocytes.
products categories :
CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
products description :
Description: Interleukin-4 Rat Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 126 amino acids and having a molecular mass of 14kDa. The IL-4 is purified by proprietary chromatographic techniques. Introduction: IL4 is a pleiotropic cytokine produced by activated T cells. IL4 is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. IL4, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
ncbi gi num :
42627877
ncbi acc num :
NP_958427.1
ncbi gb acc num :
NM_201270.1
uniprot acc num :
P20096
ncbi mol weight :
16,247 Da
ncbi pathways :
Allograft Rejection Pathway 83511!!Allograft Rejection Pathway 535!!Asthma Pathway 83508!!Asthma Pathway 532!!Autoimmune Thyroid Disease Pathway 83509!!Autoimmune Thyroid Disease Pathway 533!!Cytokine-cytokine Receptor Interaction Pathway 83443!!Cytokine-cytokine Receptor Interaction Pathway 460!!Cytokines And Inflammatory Response (BioCarta) Pathway 198521!!Fc Epsilon RI Signaling Pathway 83474
ncbi summary :
Th2-type cytokine; may be involved in inflammatory response in eosinophils [RGD, Feb 2006]
size :
0.02 mg
price :
205 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
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