product summary
request information :
company name :
MyBioSource
product type :
protein
product name :
Recombinant Mouse Interleukin-17A
catalog :
MBS142255
quantity :
1 mg
price :
2665 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS142255
products type :
Recombinant Protein
products full name :
Recombinant Mouse Interleukin-17A
products short name :
Interleukin-17A
products name syn :
IL 17 Mouse; Interleukin-17 Mouse Recombinant; CTLA-8; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8
other names :
interleukin-17A; Interleukin-17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8; interleukin 17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8
products gene name :
mIL 17
other gene names :
Il17a; Il17a; Il17; Ctla8; IL-17; Ctla-8; IL-17A; Ctla8; Il17; IL-17; IL-17A; CTLA-8
uniprot entry name :
IL17_MOUSE
host :
E Coli
sequence length :
158
sequence :
MAAIIPQSSA CPNTEAKDFL QNVKVNLKVF NSLGAKVSSR RPSDYLNRST SPWTLHRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPESCPF TFRVEKMLVG VGCTCVASIV RQAA.
purity :
Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
Lyophilized from a concentrated (1mg/ml) solution containing no additives. Sterile Filtered White lyophilized (freeze-dried) powder.
storage stability :
Lyophilized Interleukin-17 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL17 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
other info2 :
Solubility: It is recommended to reconstitute the lyophilized Interleukin 17 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Protein Content: Protein quantitation was carried out by two independent methods:1. UV spectroscopy at 280 nm using the absorbency value of 0.942 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).2. Analysis by RP-HPLC, using a standard solution of IL-17 as a Reference Standard. Biological Activity: The ED50 as determined by the dose-dependant induction of IL-6 production in cultured mouse NIH 3T3 fibroblasts was found to be 0.4 ng/ml, corresponding to a specific activity of 2,500,000 units/mg.
products categories :
CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
products description :
Description: Interleukin-17 Murine Recombinant produced in E Coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 268 (2x134 a.a.) amino acids and having a molecular mass of 30 kDa. The IL-17 is purified by proprietary chromatographic techniques. Introduction: IL17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. Interleukin-17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
ncbi gi num :
6754324
ncbi acc num :
NP_034682.1
ncbi gb acc num :
NM_010552.3
uniprot acc num :
Q62386
ncbi mol weight :
17,490 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway 83248!!Cytokine-cytokine Receptor Interaction Pathway 460!!Inflammatory Bowel Disease (IBD) Pathway 842778!!Inflammatory Bowel Disease (IBD) Pathway 842797!!Rheumatoid Arthritis Pathway 200310!!Rheumatoid Arthritis Pathway 200269
size :
1 mg
price :
2665 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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