protein

Recombinant Ovine Interferon-Tau

MBS142254

0.002 mg

140 USD

Recombinant Protein

Recombinant Ovine Interferon-Tau

Interferon-Tau

IFN tau Ovine; Interferon-Tau Ovine Recombinant; IFN-tau1; Trophoblast protein 1; TP-1; Trophoblastin; Antiluteolysin; Trophoblast antiluteolytic protein; IFN-tau; Interferon tau-1

interferon tau-1; Interferon tau-1; interferon tau-1; IFN-tau-1; IFN-tau-4; Interferon tau-4; P3; antiluteolysin; trophoblast antiluteolytic protein; trophoblast protein 1; trophoblastin; Antiluteolysin; Trophoblast antiluteolytic protein; Trophoblast protein 1; TP-1; Trophoblastin

oIFN tau

TP-1; IFNT1; OTP; IFNT1; IFNT4; OTP; IFN-tau-1; TP-1

IFNT1_SHEEP

E Coli

195

The sequence of the first five N-terminal amino acids was determined and was found to be Cys-Tyr-Leu-Ser-Arg.

Greater than 95.0% as determined by both:(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Lyophilized from (1mg/ml) solution containing PBS pH-7.4. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized Interferon-Tau although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IFN-Tau should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized Interferon Tau in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The specific activity as determined in a viral resistance assay using bovine kidney MDBK cells was found to be 10,000,000IU/mg.

CYTOKINES AND GROWTH FACTORS; Cytokines; Interferon

Description: Interferon-Tau Ovine Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids and having a molecular mass of 19914.7 Dalton.The IFN-Tau is purified by proprietary chromatographic techniques. Introduction: IFN-tau is also known as TP-1 (trophoblast protein-1) is a new class of type I IFN that is secreted by the trophoblast and is the signal for maternal recognition of pregnancy in sheep. IFN- tau has potent immunosuppressive and antiviral activities similar to other type I IFN but is less cytotoxic than IFN-alpha and IFN-beta. The current investigation concerns the effect of recombinant ovine IFN- tau (rOIFN- tau) on the modulation of MHC class I and II expression on cloned mouse cerebrovascular endothelial (CVE) cells. IFN-tau induced tyrosine phosphorylation of Stat1 and upregulated the expression of MHC class I on CVE. One proposed action by which type I IFN reduces the relapse rate in MS is via interference with IFN-?-induced MHC class II expression. IFN- tau was shown to downregulate IFN-?-induced MHC class II expression on CVE and, hence, may be of potential therapeutic value in downregulating inflammation in the central nervous system (CNS). IFN- tau did not upregulate the expression of MHC class II on CVE. IFN- tau also inhibited the replication of Theiler's virus in CVE.

183979987

NP_001116871.1

NM_001123399.1

P56828

22,193 Da

Cytokine-cytokine Receptor Interaction Pathway (1030752); Cytokine-cytokine Receptor Interaction Pathway (460); Jak-STAT Signaling Pathway (1030801); Jak-STAT Signaling Pathway (488); RIG-I-like Receptor Signaling Pathway (1030798); RIG-I-like Receptor Signaling Pathway (116128)

0.002 mg

140 USD

0.01 mg

205

1 mg

3950