catalog number :
MBS142253
products type :
Recombinant Protein
products full name :
Recombinant Porcine Interleukin-1 Receptor Antagonist
products short name :
Interleukin-1
products name syn :
IL 1RA Porcine; Interleukin-1 Receptor Antagonist Porcine Recombinant; IRAP; IL1F3; IL1RA; IL-1ra3; ICIL-1RA; IL1RN; IL1 inhibitor; IL-1ra; MGC10430
other names :
Interleukin 1 receptor antagonist; Interleukin 1 receptor antagonist; Interleukin 1 receptor antagonist
products gene name :
pIL 1RA
uniprot entry name :
Q6PUJ3_PIG
sequence :
HPLGKRPCRM QAFRIWDVNQ KTFYLRNNQL VAGYLQGPNT KLEEKIDVVP VEPHFVFLGI HGGKLCLSCV KSGDEMKLQL DAVNITDLRK NSEQDKRFTF IRSDSGPTTS FESAACPGWF LCTALEADQP VGLTNTPKAA VKVTKFYFQQ DQ
purity :
Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
The IL 1RA was lyophilized from a 0.2 um filtered concentrated solution in 1xPBS, pH 7.4, containing 1mM DTT. Sterile Filtered White lyophilized (freeze-dried) powder.
other info2 :
Solubility: It is recommended to reconstitute the lyophilized IL 1RA in sterile distilled H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1a-dependent proliferation of murine D10S cells is less than 50 ng/ml, corresponding to a specific activity of > 2.0 x 104 IU/mg in the presence of 75 pg/ml rPoIL-1a.
products categories :
CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
products description :
Description: Recombinant IL 1RA Porcine produced in E Coli cells is a non-glycosylated, homodimeric protein containing 152 amino acid chain and having a molecular mass of 17.1kDa. The IL 1RA is purified by proprietary chromatographic techniques. Introduction: Interleukin-1 ra is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
ncbi mol weight :
9,042 Da