protein

Recombinant Human Interleukin-19

MBS142240

0.01 mg

205 USD

Recombinant Protein

Recombinant Human Interleukin-19

Interleukin-19

IL 19 Human; Interleukin-19 Human Recombinant; Melanoma differentiation association like protein; MDA1; NG.1; ZMDA1; IL-10C; IL-19

interleukin-19 isoform 2; Interleukin-19; interleukin-19; melanoma differentiation associated protein-like protein; melanoma differentiation-associated protein-like protein; interleukin 19; Melanoma differentiation-associated protein-like protein; NG.1

IL 19

IL19; IL19; MDA1; NG.1; ZMDA1; IL-10C; ZMDA1; IL-19

IL19_HUMAN

E Coli

177

The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Arg-Arg-Cys.

Greater than 99.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Lyophilized from a concentrated (1mg/ml) solution in water containing 10mM sodium citrate pH-5. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized Interleukin-19 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL19 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized Interleukin -19 in sterile 18M Omega -cm H2O at a concentration of 0.5mg/ml or less. Biological Activity: The activity is determined by it's ability to activate STAT following receptor-ligand interaction.

CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin

Description: Interleukin-19 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids and having a molecular mass of 17913 Dalton. The IL-19 is purified by proprietary chromatographic techniques. Introduction: IL19 is a cytokine that belongs to the IL10 cytokine subfamily. IL-19 is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.

30795208

NP_037503.2

NM_013371.3

Q9UHD0

23,079 Da

Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!IL23-mediated Signaling Events Pathway 138000!!Jak-STAT Signaling Pathway 83077!!Jak-STAT Signaling Pathway 488

The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]

0.01 mg

205 USD