catalog number :
MBS142227
products type :
Recombinant Protein
products full name :
Recombinant Mouse Interleukin-6
products short name :
Interleukin-6
products name syn :
IL 6 Mouse; Interleukin-6 Mouse Recombinant; IFN-b2; B cell differentiation factor (BCDF); BSF-2; HPGF; HSF; MGI-2; IL-6; Interleukin HP-1; B-cell hybridoma growth factor
other names :
interleukin-6; Interleukin-6; interleukin-6; B-cell hybridoma growth factor; interleukin HP-1; interleukin 6; B-cell hybridoma growth factor; Interleukin HP-1
products gene name :
mIL 6
other gene names :
Il6; Il6; Il-6; Il-6; IL-6
uniprot entry name :
IL6_MOUSE
sequence :
FPTSQVRRGD FTEDTTPNRP VYTTSQVGGL ITHVLWEIVE MRKELCNGNS DCMNNDDALA ENNLKLPEIQ RNDGCYQTGY NQEICLLKIS SGLLEYHSYL EYMKNNLKDN KKDKARVLQR DTETLIHIFN QEVKDLHKIV LPTPISNALL TDKLESQKEW LRTKTIQFIL KSLEEFLKVT LRSTRQT.
purity :
Greater than 96.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4. Sterile Filtered White lyophilized (freeze-dried) powder.
storage stability :
Lyophilized Interleukin-6 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL6 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
other info2 :
Solubility: It is recommended to reconstitute the lyophilized Mouse Il-6 in sterile 18M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50 as determined by the dose-dependant stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is 50,000,000 units/mg.
products categories :
CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
products description :
Description: Interleukin-6 Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 187 amino acids and having a molecular mass of 21709 Dalton. The IL-6 is purified by proprietary chromatographic techniques. Introduction: Interleukin-6 is a potent pro-inflammatory cytokine primarily produced by activated T cells and an assortment of other cells including endothelial cells and macrophages. IL-6 affects B and T lymphocytes and has been shown to have a role in host defense, acute phase reactions, immune responses and hematopoiesis.
ncbi acc num :
NP_112445.1
ncbi gb acc num :
NM_031168.1
ncbi mol weight :
24,384 Da
ncbi pathways :
ARMS-mediated Activation Pathway 1110440!!Activated TLR4 Signalling Pathway 1110727!!Adipogenesis Pathway 198299!!African Trypanosomiasis Pathway 194387!!African Trypanosomiasis Pathway 194323!!Amoebiasis Pathway 167330!!Amoebiasis Pathway 167191!!Androgen Receptor Signaling Pathway 198319!!Axon Guidance Pathway 1111058!!Cellular Senescence Pathway 1111543