protein

Recombinant Human Interleukin-9

MBS142225

0.002 mg

140 USD

Recombinant Protein

Recombinant Human Interleukin-9

Interleukin-9

IL 9 Human; Interleukin-9 Human Recombinant; P40; HP40; T-cell growth factor p40; IL-9; P40 cytokine

interleukin-9; Interleukin-9; interleukin-9; T-cell growth factor p40; cytokine P40; homolog of mouse T cell and mast cell growth factor 40; p40 T-cell and mast cell growth factor; p40 cytokine; interleukin 9; Cytokine P40; T-cell growth factor P40

IL 9

IL9; IL9; P40; HP40; IL-9; IL-9

IL9_HUMAN

E Coli

144

MQGCPTLAGI LDINFLINKM QEDPASKCHC SANVTSCLCL GIPSDNCTRP CFSERLSQMT NTTMQTRYPL IFSRVKKSVE VLKNNKCPYF SCEQPCNQTT AGNALTFLKS LLEIFQKEKM RGMRGKI.

Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Lyophilized from a concentrated (1mg/ml) solution containing 10mM Na2PO4, pH 7.5. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized Interleukin-9 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL9 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized Interleukin-9 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50 as determined by the dose-dependant proliferation of human MO7e cells is < 0.5-0.7ng/ml.

CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin

Description: Interleukin-9 Human Recombinant produced in E Coli is a single, non-glycosylated single polypeptide chain containing 127 amino acids and having a molecular mass of 14,004 Dalton. The IL-9 is purified by proprietary chromatographic techniques. Introduction: Factor that is thought to be a regulator of hematopoiesis. It has been shown to enhance the growth of human mast cells and megakaryoblastic leukemic cells as well as murine helper t-cell clones. IL-9 is a glycoprotein with a molecular weight of 32-39 that is derived from T-cells, and maps to human chromosome 5.

10834980

NP_000581.1

NM_000590.1

P15248

15,909 Da

Asthma Pathway (83120); Asthma Pathway (532); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); IL-9 Signaling Pathway (198883); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); TCR Signaling Pathway (198862)

The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]

IL9: Supports IL-2 independent and IL-4 independent growth of helper T-cells. Belongs to the IL-7/IL-9 family. Protein type: Secreted; Secreted, signal peptide; Cytokine. Chromosomal Location of Human Ortholog: 5q31.1. Cellular Component: extracellular space. Molecular Function: growth factor activity; interleukin-9 receptor binding; cytokine activity. Biological Process: positive regulation of cell proliferation; immune response; inflammatory response; positive regulation of cell growth; positive regulation of interleukin-5 biosynthetic process

0.002 mg

140 USD

0.01 mg

205

1 mg

4550