protein

Recombinant Rat Interleukin-15

MBS142222

0.002 mg

140 USD

Recombinant Protein

Recombinant Rat Interleukin-15

[Interleukin-15]

[IL 15 Rat; Interleukin-15 Rat Recombinant; IL-15; MGC9721]

[interleukin-15; Interleukin-15; interleukin-15; IL-15; interleukin 15]

[rIL 15]

[Il15; Il15; IL-15]

IL15_RAT

E Coli

162

The sequence of the first five N-terminal amino acids was determined and was found to be Met-Asn-Trp-Ile-Asp

Greater than 98.0% as determined by: . (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The protein was lyophilized from 10mM Tris, pH-8.5.

Lyophilized Interleukin-15 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL15 should be stored at 4° between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder).

Solubility: It is recommended to reconstitute the lyophilized Interleukin-15 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50 as determined by the dose-dependant stimulation of the proliferation of CTLL-2 was found to be 5 IU/mg.

CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin

Description: Interleukin-15 Rat Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 115 amino acids and having a molecular mass of 13533 Dalton. The IL-15 is purified by proprietary chromatographic techniques. Introduction: The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.

6981092

NP_037261.1

NM_013129.2

P97604

Cytokine-cytokine Receptor Interaction Pathway (83443); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response (BioCarta) Pathway (198521); HTLV-I Infection Pathway (373894); HTLV-I Infection Pathway (373889); Herpes Simplex Infection Pathway (377869); Herpes Simplex Infection Pathway (377865); Intestinal Immune Network For IgA Production Pathway (128752); Intestinal Immune Network For IgA Production Pathway (128670); Jak-STAT Signaling Pathway (83469)

human homolog is a cytokine involved in the regulation of T and natural killer cell activation and proliferation [RGD, Feb 2006]

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha ().

0.002 mg

140 USD

0.01 mg

205

1 mg

4870