product summary
request information :
company name :
MyBioSource
product type :
protein
product name :
Recombinant Mouse Interleukin-15
catalog :
MBS142221
quantity :
0.01 mg
price :
205 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS142221
products type :
Recombinant Protein
products full name :
Recombinant Mouse Interleukin-15
products short name :
Interleukin-15
products name syn :
IL 15 Mouse; Interleukin-15 Mouse Recombinant; IL-15; MGC9721
other names :
interleukin-15; Interleukin-15; interleukin-15; interleukin 15; N/A
products gene name :
mIL 15
other gene names :
Il15; Il15; IL-15; AI503618; IL-15
uniprot entry name :
IL15_MOUSE
host :
E Coli
sequence length :
162
sequence :
The sequence of the first five N-terminal amino acids was determined and was found to be Met-Asn-Trp-Ile-Asp.
purity :
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
The protein was lyophilized from a concentrated (1mg/ml) solution with 10mM NaP pH 8.0. Sterile Filtered White lyophilized (freeze-dried) powder.
storage stability :
Lyophilized Interleukin-15 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL15 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
other info2 :
Solubility: It is recommended to reconstitute the lyophilized Interleukin-15 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50 as determined by the dose-dependant stimulation of the proliferation of mouse CTLL-2 was found to be 15 ng/ml, corresponding to a Specific Activity of 2 x 105 IU/mg.
products categories :
CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
products description :
Description: Interleukin-15 Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 115 amino acids and having a molecular mass of 13321 Dalton. The IL-15 is purified by proprietary chromatographic techniques. Introduction: The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.
ncbi gi num :
363000984
ncbi acc num :
NP_001241676.1
ncbi gb acc num :
NM_001254747.1
uniprot acc num :
P48346
ncbi mol weight :
18,593 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway 83248!!Cytokine-cytokine Receptor Interaction Pathway 460!!Cytokines And Inflammatory Response (BioCarta) Pathway 198283!!HTLV-I Infection Pathway 373903!!HTLV-I Infection Pathway 373889!!Herpes Simplex Infection Pathway 377874!!Herpes Simplex Infection Pathway 377865!!Intestinal Immune Network For IgA Production Pathway 128761!!Intestinal Immune Network For IgA Production Pathway 128670!!Jak-STAT Signaling Pathway 83274
size :
0.01 mg
price :
205 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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