Recombinant Human Platelet Derived Growth Factor-AA | MyBioSource MBS142218 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Platelet Derived Growth Factor-AA

catalog :

MBS142218

quantity :

0.01 mg

price :

205 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142218

products type :

Recombinant Protein

products full name :

Recombinant Human Platelet Derived Growth Factor-AA

products short name :

Platelet Derived Growth Factor-AA

products name syn :

PDGF AA Human; Platelet-Derived Growth Factor AA Human Recombinant; Glioma-derived growth factor; GDGF; Osteosarcoma-derived Growth Factor; ODGF; PDGF-AA; PDGF-1

other names :

platelet-derived growth factor subunit A isoform 1 preproprotein; Platelet-derived growth factor subunit A; platelet-derived growth factor subunit A; PDGF A-chain; PDGF subunit A; PDGF-1; platelet-derived growth factor A chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha isoform 2 preproprotein; platelet-derived growth factor alpha polypeptide; PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide

products gene name :

PDGF AA

other gene names :

PDGFA; PDGFA; PDGF1; PDGF-A; PDGF1; PDGF subunit A

uniprot entry name :

PDGFA_HUMAN

host :

E Coli

sequence length :

211

sequence :

SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTGRP RESGKKRKRK RLKPT.

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

Lyophilized without any additives. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized Platelet-Derived Growth Factor AA although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution PDGF-AA should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized Platelet-derived Growth Factor-AA in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50, calculated by the dose-dependent proliferation of murine 3T3 indicator cells is < 0.32ng/ml, corresponding to a Specific Activity of 3,125x103units/mg.

products categories :

CYTOKINES AND GROWTH FACTORS; Growth Factors; PDGF

products description :

Description: Platelet-Derived Growth Factor AA Human Recombinant is a homodimeric, non-glycosylated, polypeptide chain containing 2 x 125 amino acids and having a total molecular mass of 28511 Dalton. PDGF-AA is purified by proprietary chromatographic techniques. Introduction: PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGF is stored in platelet alpha-granules and released upon platelet activation. The PDGF is involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGF have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB.

ncbi gi num :

77695917

ncbi acc num :

NP_002598.4

ncbi gb acc num :

NM_002607.5

uniprot acc num :

P04085

ncbi mol weight :

22,253 Da

ncbi pathways :

Adaptive Immune System Pathway 366160!!Ceramide Signaling Pathway 138023!!Choline Metabolism In Cancer Pathway 1059539!!Choline Metabolism In Cancer Pathway 1084232!!Constitutive PI3K/AKT Signaling In Cancer Pathway 685535!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Cytokines And Inflammatory Response Pathway 198794!!DAP12 Interactions Pathway 685549!!DAP12 Signaling Pathway 685550

ncbi summary :

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]

size :

0.01 mg

price :

205 USD

more info or order :

MyBioSource product webpage