Recombinant Mouse Vascular Endothelial Growth Factor | MyBioSource MBS142213 product information

product summary

request information :

company name :

MyBioSource

product type :

protein

product name :

Recombinant Mouse Vascular Endothelial Growth Factor

catalog :

MBS142213

quantity :

0.01 mg

price :

205 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142213

products type :

Recombinant Protein

products full name :

Recombinant Mouse Vascular Endothelial Growth Factor

products short name :

Vascular Endothelial Growth Factor

products name syn :

VEGF Mouse; Vascular Endothelial Growth Factor Mouse Recombinant; Vascular endothelial growth factor A; VEGF-A; Vascular permeability factor; VPF; VEGF; MGC70609

other names :

vascular endothelial growth factor A isoform 1; Vascular endothelial growth factor A; vascular endothelial growth factor A; vascular permeability factor; vascular endothelial growth factor A; Vascular permeability factor; VPF

products gene name :

rmVEGF

other gene names :

Vegfa; Vegfa; Vpf; Vegf; Vegf; VEGF-A; VPF

uniprot entry name :

VEGFA_MOUSE

host :

E Coli

sequence length :

392

sequence :

MAPTTEGEQK SHEVIKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNITMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR.

purity :

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The protein was lyophilized from a concentrated (1mg/ml) solution with no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized Vascular Endothelial Growth Factor although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution VEGF should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized Vascular Endothelial Growth Factor in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The biological activity is determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1.0-5.0 ng/ml corresponding to a specific activity of 0.2-1,000,000IU/mg.

products categories :

CYTOKINES AND GROWTH FACTORS; Growth Factors; VEGF

products description :

Description: Vascular Endothelial Growth Factor Mouse Recombinant produced in E Coli is a double, non-glycosylated, polypeptide chain containing 165 amino acids and having a molecular mass of 39035 Dalton.The VEGF is purified by proprietary chromatographic techniques. Introduction: Vascular endothelial growth factor is an important signaling protein involved in both vasculogenesis and angiogenesis. As its name implies, VEGF activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g. stimulation monocyte/ macrophagemigration, neurons, cancer cells, kidney epithelial cells). VEGF mediates increased vascular permeability, induces angiogenesis, vasculogenesis and endothelial cell growth, promotes cell migration, and inhibits apoptosis. In vitro, VEGF has been shown to stimulate endothelial cell mitogenesisand cell migration. VEGF is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor.Elevated levels of this protein are linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy.

ncbi gi num :

160358799

ncbi acc num :

NP_001020421.2

ncbi gb acc num :

NM_001025250.3

uniprot acc num :

Q00731

ncbi mol weight :

40,288 Da

ncbi pathways :

Axon Guidance Pathway 1111058!!Bladder Cancer Pathway 83308!!Bladder Cancer Pathway 527!!Cellular Response To Hypoxia Pathway 1111532!!Cellular Responses To Stress Pathway 1111531!!Cytokine-cytokine Receptor Interaction Pathway 83248!!Cytokine-cytokine Receptor Interaction Pathway 460!!Developmental Biology Pathway 1111057!!EPH-Ephrin Signaling Pathway 1111085!!EPHA-mediated Growth Cone Collapse Pathway 1111086

ncbi summary :

This gene product is a member of the PDGF/VEGF growth factor family. It is a mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Also, alternative translation initiation from non-AUG (CUG) and AUG start sites in some transcript variants, give rise to additional isoforms. The expression of some isoforms derived from AUG start codon is affected by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2013]

size :

0.01 mg

price :

205 USD

more info or order :

MyBioSource product webpage