Recombinant Human Growth and Differentiation factor 15 | MyBioSource MBS142212 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Growth and Differentiation factor 15

catalog :

MBS142212

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142212

products type :

Recombinant Protein

products full name :

Recombinant Human Growth and Differentiation factor 15

products short name :

Growth and Differentiation factor 15

products name syn :

GDF15 Human; Growth and Differentiation Factor 15 Human Recombinant; GDF-15; MIC1; MIC-1; NAG-1; PDF; PLAB; PTGFB; Growth/differentiation factor 15; Placental bone morphogenetic protein; Placental TGF-beta; Macrophage inhibitory cytokine 1; Prostate differentiation factor; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; NRG-1; GDF15

other names :

growth/differentiation factor 15; Growth/differentiation factor 15; growth/differentiation factor 15; NRG-1; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PTGF-beta; macrophage inhibitory cytokine 1; placental TGF-beta; placental bone morphogenetic protein; prostate differentiation factor; growth differentiation factor 15; Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor

products gene name :

GDF15

other gene names :

GDF15; GDF15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; MIC1; PDF; PLAB; PTGFB; GDF-15; MIC-1; NAG-1; NRG-1

uniprot entry name :

GDF15_HUMAN

host :

E Coli

sequence length :

308

sequence :

MARNGDHCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI.

purity :

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

GDF15 is lyophilized without additives. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized GDF15 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution GDF15 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized GDF15 in sterile 5mM AcOH (acetic Acid) at a concentration of 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The biological activity was assessed by the inhibition of DU-145 cells and was found to be 1-2ug/ml.

products categories :

CYTOKINES AND GROWTH FACTORS; Cytokines; Bone Morphogenetic Protein

products description :

Description: GDF15 Human Recombinant produced in E Coli is a homodimeric, non-glycosylated, Polypeptide chain containing 2x113 amino acids and having a molecular mass of 24.5 kDa. The GDF15 is purified by proprietary chromatographic techniques. Introduction: GDF15 is part of the TGF-Beta superfamily that is involved in regulating inflammatory and apoptotic pathways in injured tissues and throughout disease processes. GDF15 is most abundant in the liver. Its expression in liver can be considerably up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF-15 promotes proliferation or growth arrest and differentiation due to differences in cellular differentiation. GDF15 prevents apoptosis in cerebellar granule neurons by activating Akt and inhibiting endogenously active ERK. GDF15 is a novel autocrine/endocrine factor that antagonizes the hypertrophic response and loss of ventricular performance.

ncbi gi num :

153792495

ncbi acc num :

NP_004855.2

ncbi gb acc num :

NM_004864.2

uniprot acc num :

Q99988

ncbi mol weight :

34,140 Da

ncbi pathways :

Direct P53 Effectors Pathway (137939)

ncbi summary :

Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009]

uniprot summary :

GDF15: disulfide-linked. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide; Cytokine. Chromosomal Location of Human Ortholog: 19p13.11. Cellular Component: extracellular space; extracellular region. Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding. Biological Process: regulation of apoptosis; cell-cell signaling; transforming growth factor beta receptor signaling pathway; regulation of MAPKKK cascade; signal transduction; cell development

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

3490

more info or order :

MyBioSource product webpage